{"id":"W2406525517","doi":"10.1124/mol.115.098509","title":"PDZ Protein Regulation of G Protein–Coupled Receptor Trafficking and Signaling Pathways","year":2015,"lang":"en","type":"review","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research","keywords":"PDZ domain; Postsynaptic density; Guanylate kinase; Cell biology; G protein-coupled receptor; Scaffold protein; Biology; Protein kinase A; Membrane protein; Transport protein; Signal transduction; Biochemistry; Receptor; Kinase; Postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008176571,0.0005594942,0.001289833,0.0001868304,0.00008323471,0.00002834116,0.0003330508,0.000781574,0.0002315161],"category_scores_gemma":[0.00006370938,0.0005315718,0.0003749682,0.0002129514,0.0001207529,0.000006719836,0.0002217718,0.0003425432,0.000009808503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005548329,"about_ca_system_score_gemma":0.0004448956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005274105,"about_ca_topic_score_gemma":5.151659e-7,"domain_scores_codex":[0.9970546,0.0005884025,0.0008256971,0.0008099806,0.0002828146,0.0004384677],"domain_scores_gemma":[0.998513,0.0000167808,0.0007096358,0.0003322112,0.0002377196,0.0001906911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004451019,0.00005549789,6.900813e-8,0.002657584,0.0002609807,0.00001053359,0.0000298497,0.00004886186,0.8735771,0.0001293655,0.000132626,0.1230531],"study_design_scores_gemma":[0.0005777325,0.0003876764,2.984728e-8,0.001161131,0.0003766827,0.00002503727,0.00001400711,0.0001003192,0.5075319,0.00006258675,0.4893115,0.0004514508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02909392,0.9642263,0.00361412,0.00001428737,0.0003773712,0.002522243,0.00003993731,0.0000324283,0.00007937735],"genre_scores_gemma":[0.0220331,0.966541,0.007130213,0.00009026829,0.001210626,0.001153205,0.001139816,0.0003215277,0.0003802635],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4891789,"threshold_uncertainty_score":0.9997136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03218980345691932,"score_gpt":0.3044668203002467,"score_spread":0.2722770168433274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}