{"id":"W2406687091","doi":"10.21775/cimb.012.143","title":"p53-based Anti-cancer Therapies: an Empty Promise?","year":2010,"lang":"en","type":"review","venue":"Current Issues in Molecular Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Cancer; Senescence; microRNA; Cancer research; Apoptosis; Biology; Clinical trial; Cancer cell; Cellular senescence; Computational biology; Medicine; Bioinformatics; Phenotype; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0004446095,0.0009941126,0.003110863,0.0007196594,0.00005975334,0.00003494339,0.0006672039,0.001626042,0.0003942671],"category_scores_gemma":[0.0001886339,0.0008173601,0.0008377235,0.0006572301,0.0004330538,0.00004001829,0.0001462765,0.002529985,0.0001090314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003029398,"about_ca_system_score_gemma":0.001272599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004762813,"about_ca_topic_score_gemma":0.00003012713,"domain_scores_codex":[0.9956769,0.0006907191,0.001061697,0.001439123,0.0002962209,0.0008352963],"domain_scores_gemma":[0.9973106,0.00006188532,0.0005057896,0.001650248,0.0001708214,0.0003006648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000364726,0.0005936378,0.00008678406,0.007218545,0.0002373306,0.0001328669,0.00008590947,0.000003301167,0.004082563,0.000301346,0.0001728394,0.9870484],"study_design_scores_gemma":[0.001350446,0.0003795484,0.000006647902,0.01045445,0.0007913863,0.00004704017,0.000005136141,0.00003229861,0.001250419,0.00009139394,0.9848239,0.0007672686],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000834576,0.9921495,0.00111189,0.0001567982,0.002412875,0.002841717,0.000182884,0.0001670018,0.0001427853],"genre_scores_gemma":[0.00009443572,0.9944935,0.001367736,0.0001772391,0.0005442279,0.0009018651,0.0021321,0.0002232153,0.0000656917],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9862812,"threshold_uncertainty_score":0.9997712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05857097612613672,"score_gpt":0.4466197239816846,"score_spread":0.3880487478555479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}