{"id":"W2406910702","doi":"10.1016/s0049-3848(16)30363-2","title":"Factor XI and factor XII as targets for new anticoagulants","year":2016,"lang":"en","type":"review","venue":"Thrombosis Research","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Ionis Pharmaceuticals; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Medicine; Hemostasis; Factor XI; Vitamin K antagonist; Warfarin; Thrombosis; Tissue factor pathway inhibitor; Coagulation; Tissue factor; Pharmacology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000658385,0.0006430348,0.002795507,0.0006883106,0.0003638361,0.0001523148,0.000412119,0.0006687724,0.002577804],"category_scores_gemma":[0.001144554,0.0004292869,0.0006528495,0.0004837874,0.0003310148,0.0001793468,0.0002897504,0.0005960643,0.0008482382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576651,"about_ca_system_score_gemma":0.001625747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002736427,"about_ca_topic_score_gemma":0.00001902091,"domain_scores_codex":[0.9954571,0.000264854,0.0008142421,0.00103136,0.001178911,0.001253502],"domain_scores_gemma":[0.9959807,0.001640385,0.00022761,0.0008655988,0.0004092072,0.0008765209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004874005,0.0001189762,0.0004269289,0.01109202,0.0006096804,0.00001105546,0.0002628219,3.29453e-9,0.0001147723,0.000439025,0.01781324,0.9690627],"study_design_scores_gemma":[0.00116418,0.000509813,0.003439127,0.01246015,0.0003286697,0.0000380406,0.00002307728,0.000004157817,0.0001858554,0.0005686335,0.9807997,0.0004785641],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006563622,0.9934928,0.00007208429,0.0006654582,0.0002989919,0.003374904,0.0004855476,0.0001135495,0.0008403211],"genre_scores_gemma":[0.000995941,0.9811096,0.0002621959,0.00005807588,0.001455364,0.0001512877,0.0002572028,0.0001903965,0.01551995],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9685842,"threshold_uncertainty_score":0.9999297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3279968968806954,"score_gpt":0.506516057716145,"score_spread":0.1785191608354497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}