{"id":"W2406928924","doi":"10.1021/nn505634h","title":"Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids","year":2015,"lang":"en","type":"article","venue":"ACS Nano","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of Toronto; BC Children's Hospital; University Health Network; University of British Columbia","funders":"Canadian Institutes of Health Research; Burroughs Wellcome Fund; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Crohn's and Colitis Foundation of Canada; University of British Columbia","keywords":"TLR4; Receptor; Signal transduction; Innate immune system; Lipopolysaccharide; Inflammation; Immune system; Toll-like receptor; Cell biology; Pattern recognition receptor; Peptide; Biology; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009873174,0.0002031568,0.0001282053,0.0001024926,0.0000842117,0.0001437127,0.0001350485,0.0002431851,0.0005040276],"category_scores_gemma":[0.0001347548,0.00009328424,0.0001165855,0.00005251182,0.0001302587,0.0001535545,0.0001319185,0.0002176208,0.0001190315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001590867,"about_ca_system_score_gemma":0.00006840572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001250477,"about_ca_topic_score_gemma":0.0002320488,"domain_scores_codex":[0.9999264,0.00001401279,0.000005317489,0.00001656763,0.00002196674,0.0000156372],"domain_scores_gemma":[0.9999526,0.00001491181,0.00001406078,0.000004000366,0.000007010939,0.000007456752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000312493,0.000008069283,0.0000250242,0.00001644999,0.000002766245,0.00001730078,0.00000461812,0.0001041416,0.9989341,0.00008308484,0.00001527795,0.0007580086],"study_design_scores_gemma":[0.000004681683,0.0001173773,0.0002067371,0.000001080127,0.000003120794,0.00003433357,0.000002974786,0.0005389584,0.9985988,0.00001726402,0.0004729437,0.000001831732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942793,0.0007934632,0.00312859,0.00006441134,0.00002584569,0.0000190328,0.00004459027,0.00006297088,0.001581745],"genre_scores_gemma":[0.9970252,0.0002546461,0.001862616,0.00004207774,0.000005211314,0.00001402366,0.00003767967,0.000008546403,0.0007501215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005040276,"threshold_uncertainty_score":0.001686096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171304021507204,"score_gpt":0.2339212870473863,"score_spread":0.2167908848966659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}