{"id":"W2406928924","doi":"10.1021/nn505634h","title":"Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids","year":2015,"lang":"en","type":"article","venue":"ACS Nano","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of Toronto; BC Children's Hospital; University Health Network; University of British Columbia","funders":"Canadian Institutes of Health Research; Burroughs Wellcome Fund; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Crohn's and Colitis Foundation of Canada; University of British Columbia","keywords":"TLR4; Receptor; Signal transduction; Innate immune system; Lipopolysaccharide; Inflammation; Immune system; Toll-like receptor; Cell biology; Pattern recognition receptor; Peptide; Biology; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006006456,0.0001203008,0.0002139695,0.000105341,0.00003999635,0.00001033999,0.0001566033,0.0001477807,0.0001411177],"category_scores_gemma":[0.0001534161,0.0001151029,0.00004372441,0.0001477899,0.00006649532,0.0002189073,0.00005310087,0.0001172699,0.0007127263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007647164,"about_ca_system_score_gemma":0.00007712006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009279664,"about_ca_topic_score_gemma":0.000007809151,"domain_scores_codex":[0.9988363,0.0002301463,0.0004183271,0.0001860429,0.00007002099,0.0002591361],"domain_scores_gemma":[0.9994122,0.00007022002,0.0001571406,0.0002271441,0.0001125586,0.00002068861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002949681,0.00008334003,0.001624587,0.000007775114,0.00003028385,0.000001495612,0.0006017211,0.00001863013,0.9762965,0.00006065149,0.0185864,0.002393626],"study_design_scores_gemma":[0.001507141,0.0002002622,0.0005109627,0.00003225863,0.00001536981,0.00001236588,0.0003950046,0.000006173702,0.9774799,0.00003969634,0.01967622,0.000124677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966491,0.001922986,0.00006432845,0.0002711775,0.0004707126,0.0001777582,0.0000103598,0.00003323406,0.0004003295],"genre_scores_gemma":[0.9931677,0.00003437253,0.00004351279,0.00009292708,0.0000166246,0.00002012393,0.0001296112,0.00001256842,0.006482569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00608224,"threshold_uncertainty_score":0.9160893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171304021507204,"score_gpt":0.2339212870473863,"score_spread":0.2167908848966659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}