{"id":"W2407258355","doi":"10.1007/s10815-016-0735-z","title":"Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos","year":2016,"lang":"en","type":"article","venue":"Journal of Assisted Reproduction and Genetics","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Windsor","funders":"","keywords":"AMPK; Blastocyst; Embryo; Protein kinase A; Andrology; Chemistry; Biology; Endocrinology; Internal medicine; Cell biology; Embryogenesis; Kinase; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004844226,0.0001316377,0.0002559743,0.00006241749,0.00005037034,0.00002088502,0.00007346802,0.00009627897,0.000007543495],"category_scores_gemma":[0.00004482426,0.00009203752,0.00003279246,0.00004852704,0.00009760095,0.00000909473,0.00006956677,0.00007283742,8.181603e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001690966,"about_ca_system_score_gemma":0.0000737231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005786497,"about_ca_topic_score_gemma":0.0001432116,"domain_scores_codex":[0.9987791,0.0001022716,0.0005020666,0.000286888,0.000184262,0.00014541],"domain_scores_gemma":[0.9991567,0.000008504316,0.0003314937,0.0002146311,0.0001897054,0.00009898202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001434857,0.0003856834,0.1772626,0.0003625734,0.0002983118,0.000005036633,0.001692703,0.00003030191,0.5494928,0.000009882843,0.0007718356,0.2682534],"study_design_scores_gemma":[0.003040298,0.000406301,0.303174,0.0001100251,0.00006121098,0.00005063166,0.001069732,0.000002783253,0.6325322,0.00003080761,0.0593187,0.0002033891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511423,0.04818149,0.0001038566,0.0001891968,0.0002054867,0.0001346454,0.00003166393,0.000001659571,0.000009667463],"genre_scores_gemma":[0.9837539,0.01493403,0.0008787865,0.00002389783,0.0001310991,0.000004323965,0.000008992264,0.000009832479,0.0002551368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.26805,"threshold_uncertainty_score":0.3753181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0165694190910101,"score_gpt":0.2601013932474912,"score_spread":0.2435319741564811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}