{"id":"W2407258355","doi":"10.1007/s10815-016-0735-z","title":"Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos","year":2016,"lang":"en","type":"article","venue":"Journal of Assisted Reproduction and Genetics","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Windsor","funders":"","keywords":"AMPK; Blastocyst; Embryo; Protein kinase A; Andrology; Chemistry; Biology; Endocrinology; Internal medicine; Cell biology; Embryogenesis; Kinase; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669147,0.0002858102,0.000321588,0.0003471196,0.0002373593,0.0002476559,0.0002297592,0.0002210397,0.002900416],"category_scores_gemma":[0.0001360436,0.0001580032,0.0003510627,0.0001800524,0.0002760818,0.0001918569,0.0002060679,0.000694096,0.0003697306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002238031,"about_ca_system_score_gemma":0.0004150593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006526893,"about_ca_topic_score_gemma":0.001771241,"domain_scores_codex":[0.9998591,0.00002487185,0.00002650373,0.00003348539,0.00003058721,0.00002539408],"domain_scores_gemma":[0.9998666,0.00004690589,0.00003076821,0.00001794109,0.0000125294,0.00002524765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003779233,0.00005625144,0.0003151977,0.0000799456,0.00001421473,0.0001074535,0.00003490107,0.00004219552,0.9962667,0.0002148775,0.0001867939,0.0023035],"study_design_scores_gemma":[0.00002574036,0.0002902052,0.003578792,0.00001147496,0.00002293114,0.0002266274,0.00003871725,0.0002125209,0.9913073,0.00006799659,0.004213029,0.000004672386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815902,0.006745125,0.003474728,0.0005385714,0.0002459081,0.00009116902,0.001896595,0.0001283352,0.00528928],"genre_scores_gemma":[0.9818193,0.003482131,0.005492408,0.0002656877,0.00005482561,0.0001225804,0.001856716,0.00004123696,0.006865169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002900416,"threshold_uncertainty_score":0.009702861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0165694190910101,"score_gpt":0.2601013932474912,"score_spread":0.2435319741564811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}