{"id":"W2407306171","doi":"10.1038/npjbcancer.2016.14","title":"Analytical validation of a standardized scoring protocol for Ki67: phase 3 of an international multicenter collaboration","year":2016,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Ottawa Hospital; University of Alberta; Ontario Institute for Cancer Research; Juravinski Hospital; McMaster University; Health Sciences Centre; Mount Sinai Hospital; University of British Columbia","funders":"Cure Brain Cancer Foundation; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Government of Ontario; Ontario Institute for Cancer Research; Breast Cancer Research Foundation","keywords":"Intraclass correlation; External quality assessment; Reproducibility; Medicine; Nuclear proliferation; Protocol (science); Breast cancer; Core biopsy; Confidence interval; Biomarker; Multicenter study; Nuclear medicine; Pathology; Statistics; Internal medicine; Cancer; Mathematics; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009193323,0.0001004717,0.00014725,0.00003843764,0.00002545707,0.000007749371,0.00009044746,0.00005108973,0.00009090242],"category_scores_gemma":[0.00004150948,0.00007193358,0.0000601827,0.00005359103,0.00007125581,0.00002171536,0.00003232604,0.00001317826,3.698063e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000787903,"about_ca_system_score_gemma":0.0001357285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003655649,"about_ca_topic_score_gemma":0.00003645281,"domain_scores_codex":[0.9992582,0.00002579293,0.0002296202,0.0002208602,0.0001562232,0.0001093173],"domain_scores_gemma":[0.9990297,0.00001308364,0.0001706238,0.0001637241,0.0005854141,0.00003746012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02420175,0.001233594,0.1144694,0.0001751806,0.0008003691,7.876005e-7,0.000218913,0.0001016927,0.7596403,0.0002120227,0.0006523672,0.09829367],"study_design_scores_gemma":[0.01905287,0.000343263,0.02142685,0.0001699389,0.00007279732,0.00000353602,0.00005675433,0.0001974395,0.952561,0.0000290282,0.005945812,0.0001406879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638367,0.00001248383,0.007445053,0.001077813,0.0002408026,0.02335251,0.00380251,0.00001427508,0.0002178987],"genre_scores_gemma":[0.9639215,0.000006220267,0.0009167662,0.00002262147,0.0002640237,0.03474874,0.00006263224,0.00001472728,0.00004270731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1929208,"threshold_uncertainty_score":0.2933366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02472987160192667,"score_gpt":0.3991916576170507,"score_spread":0.374461786015124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}