{"id":"W2407306171","doi":"10.1038/npjbcancer.2016.14","title":"Analytical validation of a standardized scoring protocol for Ki67: phase 3 of an international multicenter collaboration","year":2016,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Ottawa Hospital; University of Alberta; Ontario Institute for Cancer Research; Juravinski Hospital; McMaster University; Health Sciences Centre; Mount Sinai Hospital; University of British Columbia","funders":"Cure Brain Cancer Foundation; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Government of Ontario; Ontario Institute for Cancer Research; Breast Cancer Research Foundation","keywords":"Intraclass correlation; External quality assessment; Reproducibility; Medicine; Nuclear proliferation; Protocol (science); Breast cancer; Core biopsy; Confidence interval; Biomarker; Multicenter study; Nuclear medicine; Pathology; Statistics; Internal medicine; Cancer; Mathematics; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.2505805,0.003173264,0.002090047,0.003519187,0.003830309,0.002903335,0.005906333,0.003524929,0.002168932],"category_scores_gemma":[0.1197227,0.001498804,0.00315403,0.004588117,0.004740747,0.001892264,0.006274682,0.003159683,0.00182376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004291872,"about_ca_system_score_gemma":0.01882398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005839161,"about_ca_topic_score_gemma":0.004264693,"domain_scores_codex":[0.845462,0.1077598,0.009998639,0.009858919,0.02407585,0.002844789],"domain_scores_gemma":[0.8265051,0.0265747,0.01872152,0.04376441,0.07938319,0.005051186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04234535,0.05365336,0.2930858,0.007347135,0.006174792,0.0008329655,0.02293012,0.0195703,0.1376318,0.01180484,0.02293942,0.3816842],"study_design_scores_gemma":[0.0287902,0.1572703,0.5570641,0.003026018,0.004430041,0.001369504,0.006584369,0.02895047,0.1104307,0.005375789,0.09598087,0.0007276637],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.399941,0.003049315,0.3107404,0.001063306,0.0008801155,0.2692045,0.003792159,0.000994318,0.01033498],"genre_scores_gemma":[0.4054422,0.001543571,0.3886809,0.001095679,0.0003079117,0.181606,0.01750001,0.00080612,0.003017482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2505805,"threshold_uncertainty_score":0.9241676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02472987160192667,"score_gpt":0.3991916576170507,"score_spread":0.374461786015124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}