{"id":"W2407600696","doi":"10.1007/978-1-61779-337-0_8","title":"Chemoproteomic Characterization of Protein Kinase Inhibitors Using Immobilized ATP","year":2011,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Protein kinase A; Biochemistry; Kinase; Biology; c-Raf; MAP2K7; Proteome; Protein kinase inhibitor; Cell biology; Cyclin-dependent kinase 2; Chemistry; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000222115,0.0004682232,0.0003257817,0.0004375558,0.0001984514,0.0003798478,0.0003977999,0.0003049722,0.0009644957],"category_scores_gemma":[0.0003095171,0.0001851655,0.0002438631,0.0004658108,0.0002002434,0.0003151907,0.0001501515,0.0005500695,0.0004956457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002732211,"about_ca_system_score_gemma":0.0002390419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009900201,"about_ca_topic_score_gemma":0.00159428,"domain_scores_codex":[0.9997954,0.00002311653,0.00001354927,0.00004048778,0.00008796126,0.00003947016],"domain_scores_gemma":[0.9998604,0.00004783772,0.00002639168,0.00001112838,0.0000326897,0.00002162341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002287018,0.00001796956,0.00005471745,0.00001917807,0.000003444195,0.00001406224,0.000006025384,0.00005484885,0.9990783,0.00003642664,0.000021578,0.0006706143],"study_design_scores_gemma":[0.000004319284,0.00004058321,0.001052743,0.000001790449,0.000006253557,0.000029751,0.000005162929,0.000769971,0.9974235,0.00001420861,0.000649063,0.000002616462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9486269,0.003277613,0.04259659,0.0002208193,0.0000652425,0.00017266,0.001397734,0.0002416457,0.00340086],"genre_scores_gemma":[0.9555907,0.004035201,0.03131273,0.0002323039,0.00003092314,0.000212655,0.003358252,0.0001445123,0.005082787],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0009900201,"threshold_uncertainty_score":0.003226578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04013352663578717,"score_gpt":0.361180753512918,"score_spread":0.3210472268771308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}