{"id":"W2407949236","doi":"10.1016/j.cellimm.2016.05.005","title":"Protein tyrosine phosphatase 1B (PTP1B) is dispensable for IgE-mediated cutaneous reaction in vivo","year":2016,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Beatrice Hunter Cancer Research Institute; McGill University; Dalhousie University","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Degranulation; Tyrosine phosphorylation; Protein tyrosine phosphatase; Immunoglobulin E; Mast cell; Phosphorylation; Biology; Cell biology; Tyrosine; Dephosphorylation; Syk; LYN; In vivo; STAT protein; Signal transduction; Phosphatase; Immunology; Tyrosine kinase; Antibody; Receptor; Biochemistry; Proto-oncogene tyrosine-protein kinase Src; STAT3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001754213,0.0002961621,0.0004739201,0.0001987391,0.0001627042,0.00001109853,0.000291829,0.0005419221,0.003855858],"category_scores_gemma":[0.0001339207,0.0002297187,0.0001205247,0.000175517,0.0003686579,0.0001132931,0.0000950437,0.0002427592,0.001531271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001414578,"about_ca_system_score_gemma":0.00007340776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003684174,"about_ca_topic_score_gemma":0.0001263871,"domain_scores_codex":[0.99805,0.0001239578,0.0004994074,0.0005612694,0.00003540333,0.0007299322],"domain_scores_gemma":[0.998944,0.0001879146,0.0002062376,0.0005524768,0.00007937044,0.00002992788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009248759,0.0003357934,0.0001193541,0.00003231676,0.0001028292,0.00004944155,0.0001167071,1.779851e-7,0.9877292,0.003043816,0.003851038,0.003694465],"study_design_scores_gemma":[0.002990182,0.0003267136,0.0000530047,0.00004781225,0.00001979,0.00006548456,0.00003691171,0.000004391308,0.5951245,0.0002841176,0.4008412,0.0002059361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731607,0.01593685,0.001513811,0.002631473,0.001936507,0.001907151,0.0008269944,0.0002036993,0.001882841],"genre_scores_gemma":[0.9379739,0.0004145154,0.0001263787,0.0001685653,0.00005124407,0.0002251863,0.0005112587,0.00005481108,0.06047418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3969902,"threshold_uncertainty_score":0.9992462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008292760508718099,"score_gpt":0.2024355282130171,"score_spread":0.194142767704299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}