{"id":"W2408084759","doi":"10.1016/j.neuron.2016.05.003","title":"TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy","year":2016,"lang":"en","type":"article","venue":"Neuron","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":824,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; University of Alberta; National Institute on Aging; National Institutes of Health; Mayo Clinic; U.S. Department of Veterans Affairs","keywords":"Microglia; TREM2; Neuroscience; Dystrophy; Amyloid (mycology); Amyloid β; Function (biology); Cell biology; Biology; Medicine; Pathology; Immunology; Inflammation; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213611,0.0007587912,0.0004009643,0.0004857194,0.0002346273,0.0003305388,0.0002364215,0.0007382808,0.002870567],"category_scores_gemma":[0.0001949891,0.0002609499,0.0003065521,0.0001489249,0.0007004587,0.0001942152,0.0003964446,0.0006799417,0.0003946781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001550075,"about_ca_system_score_gemma":0.0002296146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003769649,"about_ca_topic_score_gemma":0.0006479914,"domain_scores_codex":[0.999793,0.00003169894,0.00002955038,0.00007715417,0.00003540794,0.00003325599],"domain_scores_gemma":[0.9998536,0.00001850243,0.00006595437,0.00001616557,0.000007168314,0.000038658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001172727,0.00009042559,0.001630267,0.0001001027,0.00006657367,0.002318638,0.00005037739,0.0001625442,0.9886245,0.0006315918,0.0003546158,0.004797725],"study_design_scores_gemma":[0.0007549712,0.002003054,0.09722354,0.0001522804,0.0006713751,0.05559896,0.0003758298,0.004696048,0.8227293,0.002333064,0.01338537,0.00007617183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946421,0.0009046749,0.002340331,0.0002248455,0.00006333161,0.00002609897,0.0007316338,0.0001700635,0.0008968145],"genre_scores_gemma":[0.9955457,0.0004937169,0.001781853,0.0001404983,0.00002917421,0.00003735383,0.000432011,0.00006643956,0.001473096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002870567,"threshold_uncertainty_score":0.009602964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213469521181938,"score_gpt":0.2394828167288257,"score_spread":0.2173481215170063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}