{"id":"W2408241851","doi":"10.1038/srep13995","title":"Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Multiple sclerosis; Experimental autoimmune encephalomyelitis; Immunology; Autoimmunity; Virus latency; Downregulation and upregulation; Virus; Epstein–Barr virus; Disease; Virology; CD8; Biology; Medicine; Immune system; Viral replication; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000171073,0.0003564833,0.0003297161,0.0003394661,0.0001687298,0.0003903565,0.0001824832,0.0003271103,0.001253679],"category_scores_gemma":[0.0001419721,0.0001502098,0.0002101895,0.000166047,0.000324689,0.0002654856,0.0002022999,0.001229802,0.000405984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002335056,"about_ca_system_score_gemma":0.0002538079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003183684,"about_ca_topic_score_gemma":0.0004068557,"domain_scores_codex":[0.999796,0.00004015404,0.00001642624,0.00003036477,0.00004466258,0.00007241636],"domain_scores_gemma":[0.9998598,0.00002062135,0.00003004635,0.00001802754,0.00001049431,0.00006094296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003947004,0.0003033556,0.0001067994,0.00003321256,0.000003359871,0.00009059694,0.00003699035,0.00003430418,0.9974279,0.0001449954,0.00005716433,0.001366662],"study_design_scores_gemma":[0.0001853132,0.005659515,0.006010944,0.00002776846,0.00005173938,0.0005457992,0.00009204492,0.001645633,0.9817194,0.0003186317,0.003730727,0.00001252543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964881,0.001084991,0.0007732674,0.0001140262,0.00006705983,0.00002201343,0.00009029878,0.0001070424,0.001253079],"genre_scores_gemma":[0.9960924,0.0006965257,0.0007932952,0.00004345649,0.00002653353,0.00003316464,0.0001347571,0.00001414239,0.002165792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253679,"threshold_uncertainty_score":0.004193902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05366143684147777,"score_gpt":0.2453044344014942,"score_spread":0.1916429975600164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}