{"id":"W2408431304","doi":"10.1038/srep20559","title":"Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; National Institute of Environmental Health Sciences; U.S. Department of Veterans Affairs; Canadian Institutes of Health Research; Canadian Liver Foundation; National Institute of General Medical Sciences; American Heart Association","keywords":"Small heterodimer partner; Gene knockdown; Farnesoid X receptor; Nuclear receptor; Bile acid; Liver injury; Downregulation and upregulation; Homeostasis; Liver receptor homolog-1; CYP8B1; Cholestasis; Cell biology; Cancer research; Chemistry; Receptor; Psychological repression; Biology; G protein-coupled bile acid receptor; Gene expression; Transcription factor; Endocrinology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007414003,0.0001246492,0.0002701507,0.0001282225,0.000161748,0.00003900307,0.00003799121,0.00008335656,0.0004373648],"category_scores_gemma":[0.0001773875,0.00007801717,0.0000953588,0.0002723406,0.0004371554,0.0001461968,0.00001998612,0.00006037571,0.000007787107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002763191,"about_ca_system_score_gemma":0.00009343107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007235088,"about_ca_topic_score_gemma":0.000004031604,"domain_scores_codex":[0.9980925,0.00001577492,0.0004840398,0.0005755803,0.0005659249,0.0002662062],"domain_scores_gemma":[0.9989021,0.00003714173,0.0001586167,0.0004982945,0.0002031506,0.0002006927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007530008,0.0000988953,0.00806164,0.0001789936,0.00003051587,0.0001709347,0.0002499105,2.994114e-8,0.9567057,0.0002743829,0.01713512,0.01701852],"study_design_scores_gemma":[0.0007256034,0.0002191529,0.008119959,0.0007065899,0.0002250326,0.0003047505,0.0005579673,0.00001663328,0.9373975,0.00645873,0.04503467,0.0002333688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901286,0.001293633,0.003083127,0.001384795,0.002571743,0.0002532678,0.00002638558,0.00006591736,0.001192574],"genre_scores_gemma":[0.9927375,0.00002174463,0.0008946239,0.00005733671,0.00005066782,0.00001084551,0.00002011949,0.00001714621,0.006189974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02789955,"threshold_uncertainty_score":0.4788837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008589479270519297,"score_gpt":0.243986888958882,"score_spread":0.2353974096883627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}