{"id":"W2408431304","doi":"10.1038/srep20559","title":"Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; National Institute of Environmental Health Sciences; U.S. Department of Veterans Affairs; Canadian Institutes of Health Research; Canadian Liver Foundation; National Institute of General Medical Sciences; American Heart Association","keywords":"Small heterodimer partner; Gene knockdown; Farnesoid X receptor; Nuclear receptor; Bile acid; Liver injury; Downregulation and upregulation; Homeostasis; Liver receptor homolog-1; CYP8B1; Cholestasis; Cell biology; Cancer research; Chemistry; Receptor; Psychological repression; Biology; G protein-coupled bile acid receptor; Gene expression; Transcription factor; Endocrinology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037731,0.0002870675,0.0001627637,0.0001664186,0.0002462852,0.0003371868,0.0001342845,0.000206942,0.001717956],"category_scores_gemma":[0.0000892589,0.0001087514,0.000168223,0.0001405066,0.000226366,0.0002739744,0.0002900909,0.0003862241,0.0004952519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002707415,"about_ca_system_score_gemma":0.000164357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002790949,"about_ca_topic_score_gemma":0.0004506243,"domain_scores_codex":[0.9999114,0.0000124261,0.000007738421,0.00002273885,0.00002547684,0.0000201638],"domain_scores_gemma":[0.9999149,0.00001037609,0.00002628851,0.000008729095,0.00001210111,0.00002744314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001255635,0.00001086035,0.001136469,0.00003216243,0.000005032773,0.0001562358,0.00001543786,0.00006152951,0.9952505,0.0003046909,0.00008849558,0.002813126],"study_design_scores_gemma":[0.00003745705,0.000268393,0.01172465,0.000008693834,0.00002152233,0.0009340088,0.00006019887,0.001600065,0.9748663,0.0002701799,0.01019821,0.00001044417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778758,0.005985752,0.01114754,0.0003633727,0.0000876221,0.00002601879,0.0005998561,0.0002431474,0.003670816],"genre_scores_gemma":[0.9933562,0.001123698,0.002181054,0.00005143839,0.00001922314,0.0000149527,0.0005604965,0.00002135362,0.002671639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001717956,"threshold_uncertainty_score":0.005747139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008589479270519297,"score_gpt":0.243986888958882,"score_spread":0.2353974096883627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}