{"id":"W2408503479","doi":"10.1158/1538-7445.sabcs15-p4-14-01","title":"Abstract P4-14-01: Trastuzumab emtansine improves overall survival versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer: Final results from the phase 3 EMILIA study","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Capecitabine; Lapatinib; Trastuzumab emtansine; Medicine; Taxane; Trastuzumab; Interim analysis; Internal medicine; Metastatic breast cancer; Gastroenterology; Confidence interval; Hazard ratio; Breast cancer; Cancer; Oncology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002416957,0.001140199,0.001800386,0.0003871268,0.0003326661,0.0009598571,0.001082698,0.000936178,0.003924478],"category_scores_gemma":[0.001112986,0.0004501656,0.003055399,0.0003750882,0.0005907619,0.0006963013,0.0004573846,0.003085988,0.0006856158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009592065,"about_ca_system_score_gemma":0.001205803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005854389,"about_ca_topic_score_gemma":0.00271594,"domain_scores_codex":[0.9993241,0.0004105588,0.00003897345,0.00008470094,0.00005257336,0.00008913772],"domain_scores_gemma":[0.9992424,0.0001345067,0.0002122634,0.00007641958,0.00005152151,0.0002827814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8816577,0.02141449,0.007815301,0.0008997943,0.004630039,0.0001323586,0.0001094842,0.002037568,0.01521702,0.0001603094,0.00553321,0.06039267],"study_design_scores_gemma":[0.6764061,0.2754216,0.035985,0.0001058685,0.003187881,0.0002066579,0.00005136127,0.001377359,0.002936952,0.0001663732,0.004108342,0.00004661314],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853204,0.005658623,0.0005487724,0.0007861679,0.0002152835,0.001950528,0.002377475,0.0001040903,0.003038637],"genre_scores_gemma":[0.9838932,0.002368825,0.001576023,0.001739519,0.0004129531,0.001796421,0.005189224,0.00003482524,0.002989051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003924478,"threshold_uncertainty_score":0.0131287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07246694683704773,"score_gpt":0.4110668480894483,"score_spread":0.3385999012524006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}