{"id":"W2408708496","doi":"10.1371/journal.ppat.1005658","title":"Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health; McGill University Health Centre; Institut National de la Recherche Scientifique","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust; McGill University","keywords":"Virulence; Cell biology; Endocytic cycle; Vacuole; Phagolysosome; Biogenesis; Biology; Mutant; Leishmania mexicana; Sulfenic acid; Phagocytosis; Leishmania; Microbiology; Cysteine; Phagosome; Endocytosis; Biochemistry; Gene; Cytoplasm; Cell; Parasite hosting; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002733117,0.0001905886,0.0003726632,0.00007089185,0.0001689332,0.00001069883,0.0002103804,0.00007891995,0.0001670033],"category_scores_gemma":[0.0008451146,0.00009223782,0.0001309355,0.0002323956,0.0002598313,0.0002055756,0.0001736124,0.0001203441,0.00007418411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000871981,"about_ca_system_score_gemma":0.00006545606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005525962,"about_ca_topic_score_gemma":0.00001710764,"domain_scores_codex":[0.9979877,0.0001468207,0.0003892999,0.0003596874,0.0007607329,0.0003557842],"domain_scores_gemma":[0.9982619,0.0003263131,0.0001784104,0.0007748336,0.0003597358,0.00009874882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001334912,0.0001542056,0.01669661,0.00009809801,0.00008184074,0.00002571474,0.0006605246,0.000006296906,0.9785148,0.0002988981,0.001249756,0.002079752],"study_design_scores_gemma":[0.001412809,0.0005811083,0.1945787,0.001219332,0.000126957,0.00002747644,0.0004447154,0.0003650901,0.7988071,0.001088219,0.001140187,0.0002083024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921232,0.0004539512,0.0004903751,0.004342426,0.00004810774,0.000613037,0.00006323189,0.00007199078,0.001793634],"genre_scores_gemma":[0.9965387,0.0003877983,0.001268657,0.0001019117,0.0002054278,0.00006637467,0.000008320024,0.00003286085,0.001389951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1797077,"threshold_uncertainty_score":0.3761349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03987654380593994,"score_gpt":0.2882049411444531,"score_spread":0.2483283973385131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}