{"id":"W2408708496","doi":"10.1371/journal.ppat.1005658","title":"Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health; McGill University Health Centre; Institut National de la Recherche Scientifique","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust; McGill University","keywords":"Virulence; Cell biology; Endocytic cycle; Vacuole; Phagolysosome; Biogenesis; Biology; Mutant; Leishmania mexicana; Sulfenic acid; Phagocytosis; Leishmania; Microbiology; Cysteine; Phagosome; Endocytosis; Biochemistry; Gene; Cytoplasm; Cell; Parasite hosting; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008267538,0.0001795504,0.0001441273,0.0001848778,0.0001789112,0.000318106,0.000111469,0.0002864974,0.000725621],"category_scores_gemma":[0.00009440993,0.00009267725,0.0001494053,0.0001345002,0.0002255053,0.0001674995,0.0002198253,0.0004498153,0.0001916686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001948215,"about_ca_system_score_gemma":0.0001230026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000713623,"about_ca_topic_score_gemma":0.0006240832,"domain_scores_codex":[0.9999238,0.00001540166,0.000005599696,0.00001504803,0.00001621034,0.00002394033],"domain_scores_gemma":[0.9999245,0.000006080087,0.00002395771,0.000007671391,0.00001137848,0.00002642944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000615567,0.00001410689,0.0001930074,0.00001191949,0.000001409981,0.0000345934,0.00001188599,0.000007909794,0.9990726,0.00003093574,0.00001455257,0.0005454451],"study_design_scores_gemma":[0.00008529779,0.0006652492,0.05537083,0.00002446777,0.00003286175,0.0005578258,0.000284787,0.001773866,0.9371688,0.0002307921,0.003792848,0.00001230398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997601,0.0009336387,0.0005606206,0.0001201546,0.000007110407,0.000009117135,0.00009830958,0.00003111829,0.0006389719],"genre_scores_gemma":[0.9984786,0.0003576367,0.0003620595,0.00002955603,0.000003231853,0.000008434836,0.00008274298,0.000006862333,0.0006709117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000725621,"threshold_uncertainty_score":0.002427459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03987654380593994,"score_gpt":0.2882049411444531,"score_spread":0.2483283973385131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}