{"id":"W2408757335","doi":"10.1515/cclm-2015-0762","title":"The side effects of translational omics: overtesting, overdiagnosis, overtreatment","year":2015,"lang":"en","type":"article","venue":"Clinical Chemistry and Laboratory Medicine (CCLM)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Overdiagnosis; Disease; Medicine; Omics; Intensive care medicine; Population; Genomics; Bioinformatics; Pathology; Genome; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0485415,0.001576626,0.002472467,0.002297055,0.00128234,0.005038037,0.001524775,0.003162972,0.00505406],"category_scores_gemma":[0.07854725,0.0006388936,0.002037114,0.00239777,0.007141392,0.004801964,0.002962453,0.008295442,0.002075263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003483931,"about_ca_system_score_gemma":0.002713977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001642029,"about_ca_topic_score_gemma":0.002196181,"domain_scores_codex":[0.961667,0.02278759,0.002625726,0.00259405,0.009740732,0.0005849608],"domain_scores_gemma":[0.8362654,0.1306312,0.009969089,0.009484788,0.01154372,0.002105824],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001516451,0.0003176664,0.03437455,0.005369546,0.001494784,0.002085771,0.001392899,0.002231583,0.009205227,0.04059914,0.07894363,0.8224688],"study_design_scores_gemma":[0.0003585427,0.002702015,0.07413615,0.009870064,0.002451582,0.01996986,0.003317105,0.009518851,0.02016667,0.3804992,0.4763763,0.0006336768],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03955743,0.3194457,0.1147842,0.4857397,0.01478711,0.0003789846,0.001715094,0.001313634,0.0222782],"genre_scores_gemma":[0.3116386,0.1699969,0.1403511,0.3468089,0.01979347,0.0006816356,0.001057914,0.0008444386,0.008827095],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9514585,"threshold_uncertainty_score":0.2567151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01979898712520587,"score_gpt":0.3141171569867287,"score_spread":0.2943181698615228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}