{"id":"W2409346424","doi":"10.1200/jco.2014.32.15_suppl.3000","title":"Randomized comparison of two doses of the anti-PD-1 monoclonal antibody MK-3475 for ipilimumab-refractory (IPI-R) and IPI-naive (IPI-N) melanoma (MEL).","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Ipilimumab; Refractory (planetary science); Clinical endpoint; Mallinckrodt; Clinical trial; Cancer; Immunotherapy; Family medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001961843,0.001455017,0.002350577,0.0004102493,0.0003040394,0.001135515,0.001259519,0.001852684,0.007799038],"category_scores_gemma":[0.00256988,0.0008723501,0.001315398,0.0003601661,0.001370961,0.0012207,0.0006236385,0.002932031,0.001349997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001098427,"about_ca_system_score_gemma":0.001288346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007284217,"about_ca_topic_score_gemma":0.001496878,"domain_scores_codex":[0.9988766,0.0005970719,0.00007843607,0.0002051399,0.00007890596,0.0001637329],"domain_scores_gemma":[0.9985122,0.0004911774,0.0003650165,0.0001455847,0.00007306705,0.000412844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9853138,0.006006186,0.0002975279,0.0001249871,0.0002577572,0.00001791457,0.00002918599,0.0002054124,0.001472267,0.00009278057,0.0002171328,0.005965117],"study_design_scores_gemma":[0.865683,0.1310497,0.001314132,0.00001931312,0.0003003922,0.00002126675,0.00002108492,0.0005812008,0.0003528626,0.0002203222,0.0004245023,0.0000123432],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896466,0.00125427,0.0007998851,0.0004022783,0.0005433624,0.005066347,0.0005150439,0.00007002962,0.001702157],"genre_scores_gemma":[0.9899593,0.0006137275,0.001294986,0.000543847,0.0002998998,0.004900457,0.0004117916,0.00001839867,0.001957596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007799038,"threshold_uncertainty_score":0.02609032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07231325230553105,"score_gpt":0.4469057133558252,"score_spread":0.3745924610502941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}