{"id":"W2409350884","doi":"10.1128/mbio.00403-16","title":"Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes","year":2016,"lang":"en","type":"article","venue":"mBio","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"Houston Methodist Research Institute; Centers for Disease Control and Prevention; Academy of Finland; Federation of European Microbiological Societies; Houston Methodist Hospital; European Society of Clinical Microbiology and Infectious Diseases; Fondren Foundation","keywords":"Streptococcus pyogenes; Pathogen; Human pathogen; Transcriptome; Disease; Biology; Microbiology; Virology; Medicine; Bacteria; Genetics; Gene; Gene expression; Staphylococcus aureus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584415,0.0001588789,0.000186612,0.0001640212,0.0001975983,0.0004335839,0.0001115419,0.0002762566,0.001203523],"category_scores_gemma":[0.0003167396,0.00008062593,0.0001673796,0.0002676096,0.0003616988,0.0001993112,0.0004689571,0.000343158,0.0002271506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001811187,"about_ca_system_score_gemma":0.0002134957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002071704,"about_ca_topic_score_gemma":0.0002823012,"domain_scores_codex":[0.9998546,0.00002942784,0.000008747151,0.00004806481,0.00002943853,0.00002975318],"domain_scores_gemma":[0.9997489,0.00006038794,0.000100031,0.00002874376,0.00002780964,0.00003416663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005904324,0.000072943,0.0570233,0.0003653538,0.00004302721,0.0003670843,0.000348154,0.0005245799,0.9186401,0.0002906755,0.0004518161,0.02128243],"study_design_scores_gemma":[0.00001519882,0.0004882087,0.8876718,0.00007096025,0.0001095331,0.001645579,0.001146236,0.002739276,0.09881107,0.001132148,0.006148153,0.00002187616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936988,0.002578169,0.001738363,0.0002298976,0.00002682949,0.00001489067,0.0006993107,0.00004721327,0.0009666109],"genre_scores_gemma":[0.9962365,0.001278846,0.00101819,0.0001361448,0.00003140853,0.00001828319,0.0007175936,0.00001046595,0.0005526266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203523,"threshold_uncertainty_score":0.004026234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03178667870126112,"score_gpt":0.311769671104334,"score_spread":0.2799829924030729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}