{"id":"W2409350884","doi":"10.1128/mbio.00403-16","title":"Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes","year":2016,"lang":"en","type":"article","venue":"mBio","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"Houston Methodist Research Institute; Centers for Disease Control and Prevention; Academy of Finland; Federation of European Microbiological Societies; Houston Methodist Hospital; European Society of Clinical Microbiology and Infectious Diseases; Fondren Foundation","keywords":"Streptococcus pyogenes; Pathogen; Human pathogen; Transcriptome; Disease; Biology; Microbiology; Virology; Medicine; Bacteria; Genetics; Gene; Gene expression; Staphylococcus aureus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349787,0.0001752106,0.0002381236,0.00006378793,0.0002019518,0.00002113337,0.00008921443,0.00005935535,0.0002022037],"category_scores_gemma":[0.0001066793,0.00008866869,0.0001523362,0.0001520204,0.00006650828,0.00004557944,0.00002239445,0.00006567138,0.0001588103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238669,"about_ca_system_score_gemma":0.0000418101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001129265,"about_ca_topic_score_gemma":0.00002813676,"domain_scores_codex":[0.998927,0.000051996,0.000265696,0.0003142193,0.0001334963,0.0003076043],"domain_scores_gemma":[0.9990633,0.00009739862,0.00004297467,0.0004422043,0.00008430477,0.0002698504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005172264,0.0001868028,0.3647887,0.000009646614,0.0001456359,0.00001863121,0.00004547626,0.000003034662,0.6188921,0.0002974401,0.006143651,0.009417171],"study_design_scores_gemma":[0.01203031,0.0008269926,0.6735926,0.0008787779,0.001385262,0.00001658576,0.0001490063,0.0001191648,0.1000919,0.003617895,0.2065445,0.0007470174],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885597,0.0007415701,0.002210929,0.006286926,0.0001320859,0.001266763,0.0003720024,0.0001218771,0.0003081084],"genre_scores_gemma":[0.9958498,0.00002829162,0.00002345271,0.0008651717,0.00009672153,0.0002594545,0.00005927571,0.00002582845,0.002792016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5188001,"threshold_uncertainty_score":0.3615804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03178667870126112,"score_gpt":0.311769671104334,"score_spread":0.2799829924030729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}