{"id":"W2409599897","doi":"10.1002/art.39560","title":"X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome","year":2015,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Toronto General Hospital; University of Toronto; Mount Sinai Hospital","funders":"National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of General Medical Sciences; National Cancer Institute; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Canada Research Chairs; College of Medicine, University of Oklahoma; National Institutes of Health; Canadian Institutes of Health Research; University of Oklahoma; Arthritis Australia; Lupus Research Alliance; Alliance for Lupus Research; Deutsche Forschungsgemeinschaft; Research to Prevent Blindness; U.S. Department of Veterans Affairs; U.S. Department of Defense","keywords":"Medicine; Odds ratio; Rheumatoid arthritis; Confidence interval; Internal medicine; Primary biliary cirrhosis; Gastroenterology; Trisomy; Autoimmune disease; Immunology; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000886075,0.0002787734,0.000327559,0.001301992,0.0001969548,0.0003845816,0.0002742784,0.00052284,0.002206252],"category_scores_gemma":[0.003068098,0.0001705276,0.0002531846,0.0007438067,0.0004437458,0.000315018,0.0003700255,0.0002759384,0.000228164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009245401,"about_ca_system_score_gemma":0.00008791182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004094597,"about_ca_topic_score_gemma":0.000352036,"domain_scores_codex":[0.9991133,0.0003364703,0.0001024661,0.00024495,0.0001451778,0.00005769478],"domain_scores_gemma":[0.9974183,0.0008794171,0.001254693,0.0001394121,0.0001476517,0.0001605014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001803095,0.000007189101,0.996735,0.00001114522,0.00003981815,0.0001423004,0.00004309551,0.00001706787,0.001385545,0.00001382773,0.00002379401,0.001400915],"study_design_scores_gemma":[0.000009593286,0.0001204784,0.9962848,0.000006272098,0.00003554195,0.002880689,0.00006995699,0.0001002036,0.0003418195,0.00004053278,0.0001075873,0.000002476109],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989256,0.00065898,0.0001239605,0.00003305649,0.00000369787,0.000001848354,0.00006053706,0.000003530838,0.0001887168],"genre_scores_gemma":[0.9996271,0.000133673,0.00008413281,0.00001495311,0.00001368278,0.000001959761,0.00005188336,0.000001638276,0.00007103534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002206252,"threshold_uncertainty_score":0.007380724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291399677952916,"score_gpt":0.2425648651426499,"score_spread":0.2296508683631207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}