{"id":"W2409599897","doi":"10.1002/art.39560","title":"X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome","year":2015,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Toronto General Hospital; University of Toronto; Mount Sinai Hospital","funders":"National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of General Medical Sciences; National Cancer Institute; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Canada Research Chairs; College of Medicine, University of Oklahoma; National Institutes of Health; Canadian Institutes of Health Research; University of Oklahoma; Arthritis Australia; Lupus Research Alliance; Alliance for Lupus Research; Deutsche Forschungsgemeinschaft; Research to Prevent Blindness; U.S. Department of Veterans Affairs; U.S. Department of Defense","keywords":"Medicine; Odds ratio; Rheumatoid arthritis; Confidence interval; Internal medicine; Primary biliary cirrhosis; Gastroenterology; Trisomy; Autoimmune disease; Immunology; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002530944,0.0001825375,0.0004900084,0.00009844258,0.00002844379,0.00001550235,0.0001431238,0.0001851795,0.00001964771],"category_scores_gemma":[0.0002118066,0.0001805431,0.00004185069,0.0000924632,0.0003756726,0.00001085245,0.000172759,0.0000937673,0.000003873301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001066875,"about_ca_system_score_gemma":0.00009689885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002002329,"about_ca_topic_score_gemma":0.0001628823,"domain_scores_codex":[0.9984461,0.0001850628,0.0006001462,0.0003813919,0.0001206373,0.0002666812],"domain_scores_gemma":[0.9993218,0.0000795817,0.0001559382,0.0002436404,0.00004927804,0.0001497866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001108445,0.0002014729,0.9925017,0.0005746426,0.00002582689,0.0001759498,0.0005168255,0.000007898782,0.002235092,0.0004583046,0.00005057974,0.003140859],"study_design_scores_gemma":[0.01920807,0.003247365,0.9229662,0.002874815,0.00005411531,0.03586832,0.005732441,0.0004854659,0.003948173,0.00380918,0.0006307061,0.001175122],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97444,0.02500073,0.000003163333,0.00008714704,0.0001036085,0.0002125754,0.00003635578,0.00001188727,0.000104489],"genre_scores_gemma":[0.9927794,0.006860706,0.00005274331,0.00004587161,0.000006689059,0.00004243081,0.0000259802,0.00001385511,0.0001722858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06953547,"threshold_uncertainty_score":0.7362334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291399677952916,"score_gpt":0.2425648651426499,"score_spread":0.2296508683631207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}