{"id":"W2409633283","doi":"10.2174/1389557515666160509125829","title":"Review of Cytotoxic CA4 Analogues that Do Not Target Microtubules: Implications for CA4 Development","year":2016,"lang":"en","type":"review","venue":"Mini-Reviews in Medicinal Chemistry","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Windsor","funders":"","keywords":"Cytotoxic T cell; Microtubule; Chemistry; Cell biology; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001552109,0.0008498898,0.003067672,0.0000934663,0.00007631958,0.00001240205,0.001102143,0.0007206682,0.000116198],"category_scores_gemma":[0.0006549964,0.0006179648,0.0009347337,0.0002457582,0.0002196036,0.000005662497,0.0002510385,0.000339748,0.00002286126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001800085,"about_ca_system_score_gemma":0.001034679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003137246,"about_ca_topic_score_gemma":0.000007719993,"domain_scores_codex":[0.9957118,0.000163611,0.002265886,0.001063644,0.0002012291,0.0005938422],"domain_scores_gemma":[0.9968326,0.0001234996,0.001373268,0.001313651,0.0001531744,0.0002038022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001217194,0.0001140236,0.00002259677,0.2939544,0.0001950517,0.000002196239,0.00002177496,1.742199e-8,0.02009168,0.000004168203,0.02769406,0.6578878],"study_design_scores_gemma":[0.0002799943,0.00004043512,0.000003055045,0.179101,0.0003419043,0.00007648268,0.000008791656,5.55142e-8,0.01255869,0.000006503844,0.8070624,0.0005206708],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003416496,0.9953218,0.0007353655,0.0001248316,0.0001343278,0.002561154,0.0007189966,0.000009737445,0.0003596756],"genre_scores_gemma":[0.000008297035,0.9888329,0.003505501,0.000674215,0.0004668673,0.002222718,0.0034448,0.00009284388,0.000751866],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7793683,"threshold_uncertainty_score":0.9996272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04955457320813372,"score_gpt":0.349008924551681,"score_spread":0.2994543513435473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}