{"id":"W2409673291","doi":"10.1177/135965350901400408","title":"Pharmacokinetics and tolerability of once- versus twice-daily lopinavir/ritonavir treatment in HIV-1-infected children","year":2008,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Abbott Laboratories","keywords":"Lopinavir; Lopinavir/ritonavir; Ritonavir; Medicine; Tolerability; Regimen; Pharmacokinetics; Gastroenterology; Internal medicine; Area under the curve; Interquartile range; Pharmacology; Viral load; Human immunodeficiency virus (HIV); Adverse effect; Antiretroviral therapy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007558597,0.0002623488,0.0005111184,0.0001204764,0.00005987614,0.000005777208,0.00005758848,0.00008017221,0.00004711788],"category_scores_gemma":[0.000009582619,0.000200966,0.0000990882,0.000264962,0.0001811406,0.00006997981,0.00002039305,0.0001106154,0.00002005917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001225679,"about_ca_system_score_gemma":0.0001161121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001672586,"about_ca_topic_score_gemma":0.0000277933,"domain_scores_codex":[0.9987885,0.00007420836,0.0003410895,0.0003313929,0.0002005407,0.000264252],"domain_scores_gemma":[0.9994835,0.00008155197,0.00008271143,0.0002300136,0.00004650787,0.00007569428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002337471,0.001460551,0.9333606,0.00001061352,0.0002724715,0.00008683425,0.001407207,8.864978e-7,0.004830212,0.00002143471,0.000109341,0.05610235],"study_design_scores_gemma":[0.02185348,0.001423422,0.9180149,0.00005195336,0.00005958146,0.00002964284,0.00003547958,0.00004600362,0.05474895,0.00001455241,0.00351315,0.0002088572],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996254,0.0008623766,0.000004743888,0.0006986964,0.00008069682,0.0007514984,0.00002104903,0.00004745693,0.001279511],"genre_scores_gemma":[0.9917006,0.006358009,0.0005483659,0.00004782158,0.00006819276,0.00003199141,0.00009406028,0.00002176653,0.001129205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05589349,"threshold_uncertainty_score":0.8195156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0372966081615957,"score_gpt":0.3080834538995758,"score_spread":0.2707868457379801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}