{"id":"W2409682988","doi":"10.1210/en.2016-1028","title":"Role of mTOR Inhibitors in Growth Hormone-Producing Pituitary Adenomas Harboring Different FGFR4 Genotypes","year":2016,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"Canadian Institutes of Health Research","keywords":"Fibroblast growth factor receptor 4; Prolactin; Endocrinology; Biology; Internal medicine; PI3K/AKT/mTOR pathway; Pituitary tumors; Cancer research; Mechanistic target of rapamycin; Fibroblast growth factor receptor; Growth factor; Receptor; Pituitary adenoma; Fibroblast growth factor; Signal transduction; Adenoma; Hormone; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195527,0.0004897782,0.0005202725,0.0003179795,0.0001589716,0.0003145708,0.0002322615,0.0003034215,0.00109215],"category_scores_gemma":[0.0001590527,0.000132239,0.0004158847,0.0001593282,0.0002415064,0.0002438935,0.0001356077,0.0006620151,0.0001959592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003069666,"about_ca_system_score_gemma":0.0002789659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008520765,"about_ca_topic_score_gemma":0.002539783,"domain_scores_codex":[0.9998604,0.00002725532,0.00001483475,0.0000256038,0.00003995036,0.00003205901],"domain_scores_gemma":[0.9998871,0.0000255575,0.00003935387,0.000009336423,0.000009373296,0.00002922231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004218741,0.0004723088,0.001270481,0.0001737477,0.00008091524,0.0002861885,0.00002991455,0.0003410499,0.9758661,0.0001647181,0.0002894485,0.01680625],"study_design_scores_gemma":[0.0006783641,0.02412852,0.02664083,0.00002528179,0.0003202794,0.001915738,0.0001526599,0.00271822,0.9362186,0.0001696578,0.006996205,0.00003566817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956644,0.002610889,0.0003383113,0.0001128881,0.0000305159,0.000025991,0.0002837866,0.00008352729,0.0008496747],"genre_scores_gemma":[0.9955286,0.001815188,0.001069775,0.00005034571,0.0000182906,0.0000396538,0.0005881757,0.00002376342,0.0008662716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109215,"threshold_uncertainty_score":0.003653586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009662964673110732,"score_gpt":0.2306226381382591,"score_spread":0.2209596734651483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}