{"id":"W2409851494","doi":"10.1021/acs.bioconjchem.5b00237","title":"Production and Characterization of a Camelid Single Domain Antibody–Urease Enzyme Conjugate for the Treatment of Cancer","year":2015,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Helix Biopharma (Canada)","funders":"Directorate for Biological Sciences","keywords":"Chemistry; Conjugate; Immunoconjugate; Antibody; Urease; Linker; Enzyme; A549 cell; Biochemistry; Molecular biology; Cell; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002666777,0.0003019019,0.0004048751,0.0002865542,0.000124373,0.000279129,0.0002636925,0.0004262032,0.0005239887],"category_scores_gemma":[0.0001908448,0.0001341794,0.0003595371,0.0002000228,0.0001377757,0.0002061701,0.0001836881,0.0002572349,0.0004250659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003689998,"about_ca_system_score_gemma":0.0001150536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001806581,"about_ca_topic_score_gemma":0.0001553469,"domain_scores_codex":[0.9998556,0.00002363342,0.00001417045,0.00002592568,0.00005887227,0.00002167885],"domain_scores_gemma":[0.9999192,0.000009838436,0.00002193102,0.00001093736,0.00002112622,0.00001706703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001903463,0.00001415422,0.00009339316,0.00002873771,0.000003760415,0.00003172522,0.000007678514,0.00005193836,0.9987389,0.00002881903,0.00002875816,0.0009530763],"study_design_scores_gemma":[0.00001200702,0.0002861206,0.001491515,0.000003895577,0.00001234284,0.0002175331,0.000004466267,0.0005753963,0.9947512,0.00001170181,0.00262966,0.000004219275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788105,0.001686272,0.0167308,0.0001647493,0.00003618571,0.0002584095,0.0006154366,0.0001414017,0.001556239],"genre_scores_gemma":[0.9808569,0.001117061,0.01353327,0.0001687647,0.00003847976,0.0001855078,0.001658826,0.0000363775,0.002404838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005239887,"threshold_uncertainty_score":0.002677262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04666699829128002,"score_gpt":0.3336634357684028,"score_spread":0.2869964374771228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}