{"id":"W2409851494","doi":"10.1021/acs.bioconjchem.5b00237","title":"Production and Characterization of a Camelid Single Domain Antibody–Urease Enzyme Conjugate for the Treatment of Cancer","year":2015,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Helix Biopharma (Canada)","funders":"Directorate for Biological Sciences","keywords":"Chemistry; Conjugate; Immunoconjugate; Antibody; Urease; Linker; Enzyme; A549 cell; Biochemistry; Molecular biology; Cell; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158438,0.0001196378,0.0002462474,0.00001947018,0.00004230922,0.000007549907,0.00004487759,0.00006048687,0.00003144493],"category_scores_gemma":[0.00005011297,0.00007415481,0.00006724193,0.00007877902,0.0002450391,0.00003071769,0.00001547872,0.00003645758,7.754184e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000512116,"about_ca_system_score_gemma":0.0001307803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002360619,"about_ca_topic_score_gemma":0.000006805652,"domain_scores_codex":[0.9992531,0.00001252961,0.0002251462,0.0001901174,0.0001713075,0.0001477958],"domain_scores_gemma":[0.9992902,0.0000373779,0.0001304012,0.0001729181,0.0002528142,0.0001163152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001201925,0.0003140795,0.005076496,0.0004777933,0.0001236371,0.000002642151,0.0004003555,9.444307e-7,0.9895882,0.00001811517,0.00008480231,0.00271102],"study_design_scores_gemma":[0.001092872,0.0004581862,0.002769939,0.0001095436,0.00009324298,0.00002168136,0.0001500923,0.00008202347,0.9732935,0.00003763296,0.02181885,0.00007239902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994626,0.002121742,0.00002595709,0.002177861,0.00007858834,0.0006102816,0.0002069942,0.000009916307,0.0001426006],"genre_scores_gemma":[0.9950545,0.001719424,0.0001160897,0.00003419642,0.0003671848,0.00009449132,0.0002086424,0.00001332693,0.002392107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02173405,"threshold_uncertainty_score":0.3023945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04666699829128002,"score_gpt":0.3336634357684028,"score_spread":0.2869964374771228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}