{"id":"W2409902809","doi":"10.1373/clinchem.2016.260331","title":"Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?","year":2016,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University Health Network; University of Toronto","funders":"Guardant Health; National Cancer Institute","keywords":"Biomarker; DNA; Cancer; Circulating tumor DNA; Computational biology; Medicine; Cancer research; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02071289,0.001079965,0.003012918,0.002507558,0.00149791,0.005499264,0.002767317,0.008896777,0.002720672],"category_scores_gemma":[0.04244804,0.0005576188,0.0009536349,0.001894092,0.01575556,0.01562087,0.002723135,0.01469472,0.002004624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003107074,"about_ca_system_score_gemma":0.002648968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002271448,"about_ca_topic_score_gemma":0.00156367,"domain_scores_codex":[0.993449,0.002627797,0.0007991296,0.001159499,0.001665675,0.0002987961],"domain_scores_gemma":[0.9522414,0.03367682,0.003120354,0.002318469,0.007204921,0.001437937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007619245,0.0001971227,0.008383313,0.006783212,0.0005684681,0.002881537,0.002313831,0.0009556019,0.004215642,0.2420052,0.2445733,0.4863608],"study_design_scores_gemma":[0.0001030534,0.0004884158,0.002856312,0.005071872,0.0002973834,0.007522072,0.002088544,0.00154149,0.003500905,0.2447728,0.7314712,0.000285931],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003016475,0.5974636,0.007108516,0.3721847,0.0164656,0.0000247503,0.000137182,0.00006754445,0.00353165],"genre_scores_gemma":[0.08504292,0.5818668,0.01187037,0.2232758,0.09214292,0.0001638168,0.0002640136,0.0001272992,0.005246026],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02071289,"threshold_uncertainty_score":0.1095416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04383586253365438,"score_gpt":0.3687122017340682,"score_spread":0.3248763392004138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}