{"id":"W2410015475","doi":"","title":"AR47A6.4.2, a functional naked monoclonal antibody targeting Trop-2, demonstrates in vivo efficacy in human pancreatic, colon, breast and prostate cancer models","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arius3D (Canada)","funders":"","keywords":"Pancreatic cancer; In vivo; Cancer research; Monoclonal antibody; Cancer; Cytotoxicity; Antibody; Signal transduction; Prostate cancer; Colorectal cancer; Biology; In vitro; Immunology; Medicine; Internal medicine; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002977548,0.0005215739,0.0003636508,0.0004669963,0.0001202545,0.000198674,0.0002765871,0.0003517818,0.001644307],"category_scores_gemma":[0.0001038276,0.0001814541,0.0003442611,0.0002025151,0.0001612774,0.0001833138,0.0001096959,0.0006925542,0.0004791513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307262,"about_ca_system_score_gemma":0.0002286605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007709684,"about_ca_topic_score_gemma":0.0008822532,"domain_scores_codex":[0.9998103,0.00003178127,0.00001288919,0.00003977122,0.00006199484,0.00004334186],"domain_scores_gemma":[0.9998869,0.00001808617,0.00003642742,0.00001629203,0.00002060814,0.0000216861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002044786,0.0001411006,0.0001133159,0.00005977934,0.00001055333,0.0000329776,0.000008882796,0.00006970136,0.9969143,0.0000386853,0.0001375918,0.002268599],"study_design_scores_gemma":[0.00004298033,0.001908856,0.001789194,0.000004866449,0.00003539268,0.0004011229,0.00000692065,0.0006106434,0.9928709,0.00001210239,0.002313157,0.000003853238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784494,0.005847665,0.009142565,0.0002257814,0.0001164363,0.0001028493,0.000746619,0.000488427,0.004880268],"genre_scores_gemma":[0.9804187,0.00317645,0.007273959,0.00008005568,0.00003118958,0.0001110751,0.001863996,0.00005612144,0.006988254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644307,"threshold_uncertainty_score":0.005500793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04104305582426208,"score_gpt":0.36784482769629,"score_spread":0.3268017718720279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}