{"id":"W2410105556","doi":"10.1101/056564","title":"iSUMO - integrative prediction of functionally relevant SUMOylation events","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University; U.S. Department of Defense; National Institutes of Health; National Science Foundation","keywords":"SUMO protein; False positive paradox; Function (biology); Protein function; Posttranslational modification; Protein–protein interaction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00174138,0.001407174,0.001139451,0.002372271,0.0005099776,0.001211447,0.0008250335,0.0007145546,0.002265667],"category_scores_gemma":[0.002552568,0.000307891,0.001323739,0.001132118,0.0002617006,0.0006317616,0.001126264,0.0006023908,0.0009979469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005865456,"about_ca_system_score_gemma":0.0006476294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001287327,"about_ca_topic_score_gemma":0.002437994,"domain_scores_codex":[0.999315,0.0001657614,0.00004803415,0.0002195766,0.0001660555,0.00008552061],"domain_scores_gemma":[0.9991033,0.0003597111,0.0001606832,0.0001502973,0.0001325972,0.00009343338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.006062212,0.0011682,0.3038623,0.001857927,0.002131361,0.001145864,0.0002814172,0.1985116,0.1928002,0.00683993,0.05725577,0.2280831],"study_design_scores_gemma":[0.0001270488,0.0003817063,0.04758202,0.00004287739,0.000164437,0.0002935989,0.00009066665,0.8869951,0.05176693,0.002889473,0.009599298,0.0000668444],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"software","genre_scores_codex":[0.7813621,0.001632104,0.1485844,0.0004372679,0.0002781739,0.0002513172,0.03273291,0.02970886,0.005012959],"genre_scores_gemma":[0.7945873,0.0002793558,0.1353749,0.0001551546,0.00006769198,0.0002345508,0.06687109,0.0007592973,0.001670693],"genre_candidate":"software","genre_consensus":null,"teacher_disagreement_score":0.002372271,"threshold_uncertainty_score":0.009209394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301973999209078,"score_gpt":0.2182903788398736,"score_spread":0.2052706388477828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}