{"id":"W2410408783","doi":"10.1016/j.clinthera.2010.02.009","title":"","year":2010,"lang":"en","type":"letter","venue":"Clinical Therapeutics","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Bioequivalence; Medicine; Medical physics; Pharmacology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","open_science","research_integrity"],"consensus_categories":["metaresearch","metaepi_narrow","research_integrity"],"category_scores_codex":[0.03742924,0.002796024,0.009782285,0.0003541564,0.0005350096,0.0005372208,0.006137247,0.0470534,0.0006555133],"category_scores_gemma":[0.3534386,0.002299687,0.005175481,0.000835086,0.005394887,0.0001951608,0.001344594,0.1099066,0.0001464658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000154853,"about_ca_system_score_gemma":0.0008141387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001073608,"about_ca_topic_score_gemma":0.00001734765,"domain_scores_codex":[0.9558724,0.01841105,0.01479487,0.00425063,0.003403138,0.003267965],"domain_scores_gemma":[0.4574779,0.5290053,0.004880963,0.006742812,0.001189513,0.0007034893],"domain_codex":null,"domain_gemma":"methods","domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004152901,0.001164779,0.0007785443,0.0006573506,0.002602387,0.001587551,0.00005983814,1.188726e-7,0.00003449313,0.008026936,0.909088,0.07558469],"study_design_scores_gemma":[0.002247214,0.0007792296,0.00009599373,0.0002059559,0.002165362,0.00003827127,0.000007835029,0.00005632698,0.00005405277,0.5145257,0.4783827,0.001441311],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001279175,0.0001365393,0.07220646,0.8971124,0.02332194,0.00314493,0.0007191403,0.001361359,0.0007180384],"genre_scores_gemma":[0.00001970545,0.0004941894,0.4479084,0.5025024,0.04732828,0.0001759729,0.00003823336,0.0005834203,0.0009494137],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.5105942,"threshold_uncertainty_score":0.99924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.876935786707712,"score_gpt":0.6757686286756017,"score_spread":0.2011671580321103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}