{"id":"W2410485947","doi":"10.1097/00007890-200402150-00008","title":"Monitoring Of NFAT-Regulated Gene Expression in the Peripheral Blood of Allograft Recipients: A Novel Perspective Towards Individual Optimized Drug Doses of Cyclosporine A.","year":2004,"lang":"en","type":"letter","venue":"Transplantation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Liver transplantation; Therapeutic drug monitoring; Calcineurin; Nephrotoxicity; Ciclosporin; Transplantation; Internal medicine; Immunosuppression; Drug; Heart transplantation; Incidence (geometry); Chronic allograft nephropathy; Tacrolimus; Immunosuppressive drug; Gastroenterology; Urology; Kidney; Kidney transplantation; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009465867,0.0004852833,0.0006464059,0.0004668325,0.0001270735,0.0006938894,0.0003549524,0.0005610382,0.0005618695],"category_scores_gemma":[0.0004796672,0.0001964196,0.0002030263,0.0003071627,0.0004110922,0.0005284975,0.0002148331,0.00100173,0.0001387959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003115218,"about_ca_system_score_gemma":0.0002473741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001506108,"about_ca_topic_score_gemma":0.0002640578,"domain_scores_codex":[0.9996675,0.0001166518,0.00002030866,0.00007032224,0.0001034191,0.0000217617],"domain_scores_gemma":[0.9996568,0.00009518471,0.00008763919,0.00003339739,0.00006283554,0.00006423626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009228004,0.0001050995,0.003081665,0.0001639145,0.00002190514,0.00005803557,0.00002704583,0.0001929318,0.9633385,0.0001799712,0.0001757874,0.03173227],"study_design_scores_gemma":[0.0001739234,0.006909535,0.04465458,0.00008541495,0.0002019472,0.001881085,0.0001059367,0.008297877,0.9260149,0.00118706,0.0104358,0.00005187739],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.7473369,0.1070558,0.1385384,0.002358096,0.0003558713,0.0002569557,0.0006424765,0.0007163408,0.002739126],"genre_scores_gemma":[0.8449715,0.0240204,0.1273605,0.0008844796,0.0004797083,0.000197969,0.0003532415,0.00005816033,0.001674133],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.0009465867,"threshold_uncertainty_score":0.005006075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717105792422084,"score_gpt":0.2656399391568532,"score_spread":0.2484688812326324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}