{"id":"W2410485947","doi":"10.1097/00007890-200402150-00008","title":"Monitoring Of NFAT-Regulated Gene Expression in the Peripheral Blood of Allograft Recipients: A Novel Perspective Towards Individual Optimized Drug Doses of Cyclosporine A.","year":2004,"lang":"en","type":"letter","venue":"Transplantation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Liver transplantation; Therapeutic drug monitoring; Calcineurin; Nephrotoxicity; Ciclosporin; Transplantation; Internal medicine; Immunosuppression; Drug; Heart transplantation; Incidence (geometry); Chronic allograft nephropathy; Tacrolimus; Immunosuppressive drug; Gastroenterology; Urology; Kidney; Kidney transplantation; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002264397,0.0002551145,0.0003562919,0.0001117113,0.00002377217,0.000007347578,0.0003929278,0.0003292847,0.000008218342],"category_scores_gemma":[0.00003289239,0.0002126249,0.0001902149,0.0001630449,0.0001342725,0.000007566227,0.00002317075,0.0002947045,6.339705e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002710105,"about_ca_system_score_gemma":0.0001562236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002498869,"about_ca_topic_score_gemma":0.000007780176,"domain_scores_codex":[0.9983417,0.0001393655,0.0005160547,0.0003578324,0.0004572647,0.0001877331],"domain_scores_gemma":[0.999007,0.00003634375,0.0004005994,0.0003299119,0.0002034164,0.00002268157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009520503,0.000370801,0.002214621,0.0004280365,0.0002657411,0.00004366152,0.004329191,0.003529472,0.987627,0.000002850904,0.0001959169,0.00004071326],"study_design_scores_gemma":[0.004024127,0.0001853001,0.009503817,0.0007170346,0.0004251111,0.00001975473,0.0003280018,0.000003155283,0.9845346,0.00003045991,0.00002874558,0.0001999259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957412,0.0005522922,0.0006896258,0.001391186,0.0001671713,0.0004252033,0.0009943857,0.000008022209,0.00003091414],"genre_scores_gemma":[0.9893111,0.0004346906,0.006713211,0.0009101595,0.0003473321,0.0000487113,0.002182577,0.00003657707,0.00001564181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007289195,"threshold_uncertainty_score":0.8670592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717105792422084,"score_gpt":0.2656399391568532,"score_spread":0.2484688812326324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}