{"id":"W2410582071","doi":"10.1189/jlb.69.5.803","title":"Phosphatidylinositol 3-kinase inhibitors prevent mouse cytotoxic T-cell development in vitro","year":2001,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cytotoxic T cell; Biology; CTL*; CD28; T cell; CD8; Cell biology; Granzyme A; Perforin; Granzyme; CD3; Granzyme B; IL-2 receptor; Molecular biology; Immunology; Antigen; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002847177,0.0008447539,0.0006466543,0.0003941042,0.0001777489,0.00060031,0.0005889898,0.0003758044,0.002406753],"category_scores_gemma":[0.0004041982,0.0002983118,0.0004031724,0.0002509295,0.0002016274,0.0002452105,0.0003640116,0.001598055,0.002089033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005721671,"about_ca_system_score_gemma":0.0005496319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007563852,"about_ca_topic_score_gemma":0.001222259,"domain_scores_codex":[0.9993786,0.0001159164,0.00007665248,0.0000754877,0.0001673432,0.0001859772],"domain_scores_gemma":[0.9994716,0.0001789157,0.00009133496,0.0001123168,0.00005155963,0.00009418886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000377227,0.0002602721,0.0001017522,0.00006541303,0.00001007947,0.00005513174,0.00002306295,0.0002152928,0.9960932,0.000176664,0.0001924224,0.002429384],"study_design_scores_gemma":[0.00005308595,0.0006502132,0.0005795408,0.000008230943,0.00001619889,0.00007498009,0.000005598672,0.00100073,0.9950297,0.0000445197,0.002534215,0.000002850586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662547,0.005387865,0.01171914,0.0002837993,0.0003388198,0.0002100362,0.002311972,0.0009664946,0.01252728],"genre_scores_gemma":[0.9735811,0.002482997,0.005268213,0.0002043302,0.00008508974,0.0002891577,0.005523436,0.0001507572,0.01241499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002406753,"threshold_uncertainty_score":0.008051395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133919612732774,"score_gpt":0.2520731144256584,"score_spread":0.2407339182983307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}