{"id":"W2410817546","doi":"10.1021/cc060098z","title":"2β-(<i>N</i>-Substituted Piperazino)-5α-Androstane-3α,17β-Diols:  Parallel Solid-Phase Synthesis and Antiproliferative Activity on Human Leukemia HL-60 Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Combinatorial Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Androstane; Chemistry; Stereochemistry; Steroid; Leukemia; Combinatorial chemistry; Hormone; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007925769,0.0003952024,0.0007096119,0.0000594487,0.00022243,0.0000938507,0.0003494883,0.0004623563,0.00005958875],"category_scores_gemma":[0.0004355198,0.0003480379,0.0004039,0.0001523655,0.0002042393,0.000024324,0.00010082,0.0004907384,0.000002666587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597474,"about_ca_system_score_gemma":0.0001764894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001715274,"about_ca_topic_score_gemma":0.000003064745,"domain_scores_codex":[0.9978546,0.00007497024,0.0007104842,0.0004443211,0.0004808314,0.0004347844],"domain_scores_gemma":[0.9981114,0.0001721867,0.0006421049,0.0003764199,0.0003005259,0.0003973187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001353588,0.0005435669,0.0002883299,0.00005476083,0.0003124958,0.0001127205,0.00003329218,0.00003198039,0.9957164,0.0000303023,0.0008656062,0.0006569651],"study_design_scores_gemma":[0.002768015,0.0002845629,0.0002608915,0.00009815687,0.00016084,0.00007262068,0.00006749989,0.00002725371,0.993422,0.0002253573,0.002224243,0.0003885744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975906,0.0002970387,0.0003290243,0.00007786278,0.0003421403,0.00009646002,0.00002881288,0.00001132214,0.001226756],"genre_scores_gemma":[0.9977574,0.00022667,0.0001242259,0.00005719997,0.001630993,0.000004630768,0.00001646387,0.00003588543,0.0001465375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002294407,"threshold_uncertainty_score":0.9998972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309300567212363,"score_gpt":0.3113919998603804,"score_spread":0.2982989941882568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}