{"id":"W2410817546","doi":"10.1021/cc060098z","title":"2β-(<i>N</i>-Substituted Piperazino)-5α-Androstane-3α,17β-Diols:  Parallel Solid-Phase Synthesis and Antiproliferative Activity on Human Leukemia HL-60 Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Combinatorial Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Androstane; Chemistry; Stereochemistry; Steroid; Leukemia; Combinatorial chemistry; Hormone; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007599137,0.0004839676,0.0002895037,0.0002497792,0.0001161525,0.0001820456,0.0001851724,0.0001156826,0.00181449],"category_scores_gemma":[0.00008044001,0.0001351451,0.0002237594,0.0003650177,0.0001191294,0.000172012,0.0002059487,0.0003019399,0.0008047977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021903,"about_ca_system_score_gemma":0.0002384428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003530788,"about_ca_topic_score_gemma":0.001046124,"domain_scores_codex":[0.9999313,0.000009360017,0.000004842257,0.00001564358,0.00001918515,0.00001962315],"domain_scores_gemma":[0.9999485,0.000005566047,0.00001349662,0.000007082392,0.000007271612,0.0000180994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002738054,0.00009754482,0.0002294109,0.0001195789,0.00001116221,0.0001123908,0.00002924247,0.0006065537,0.9822368,0.0001686121,0.0001362417,0.01597863],"study_design_scores_gemma":[0.00009860771,0.001684439,0.001778613,0.00001139677,0.00004748364,0.0003883062,0.00002411442,0.0005292771,0.9845504,0.00006453778,0.01080675,0.00001592307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782577,0.003597115,0.007765251,0.00007641555,0.00004425419,0.0002289944,0.001759397,0.0002619836,0.008008973],"genre_scores_gemma":[0.9677155,0.005080129,0.01570979,0.0001195489,0.00002710366,0.0002219938,0.002535222,0.00006670046,0.008523948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00181449,"threshold_uncertainty_score":0.006070077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309300567212363,"score_gpt":0.3113919998603804,"score_spread":0.2982989941882568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}