{"id":"W2410894294","doi":"10.1016/j.ahj.2016.05.010","title":"Evaluating bococizumab, a monoclonal antibody to PCSK9, on lipid levels and clinical events in broad patient groups with and without prior cardiovascular events: Rationale and design of the Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Lipid Lowering and SPIRE Cardiovascular Outcomes Trials","year":2016,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Pfizer","keywords":"PCSK9; Medicine; Spire (mollusc); Placebo; Internal medicine; Residual risk; Statin; Cholesterol; Disease; Clinical trial; Cardiology; Virology; Lipoprotein; LDL receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01183397,0.0002854186,0.002312318,0.0001835886,0.0002210908,0.00001188891,0.00005874397,0.00007493301,0.000001515334],"category_scores_gemma":[0.001684164,0.0001427222,0.0006562414,0.0002571463,0.0006640815,0.0001696373,0.0001362966,0.0002819246,1.076271e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008541373,"about_ca_system_score_gemma":0.000200011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002936809,"about_ca_topic_score_gemma":0.000008918611,"domain_scores_codex":[0.9942188,0.002459652,0.001284253,0.0004722148,0.001299711,0.0002653956],"domain_scores_gemma":[0.9978325,0.0005022792,0.0006317701,0.0004891856,0.0003571279,0.0001870824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003715777,0.000288346,0.6493878,0.0005190623,0.01094343,0.000005973975,0.003051323,0.0006665683,0.004588375,0.00001286149,0.000007084345,0.3268134],"study_design_scores_gemma":[0.01558348,0.00340978,0.9713176,0.003179656,0.002024489,0.0007830639,0.001804962,0.00009962828,0.001360348,0.0001025653,0.0001035573,0.0002308346],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847732,0.01021015,0.001517647,0.0006845976,0.0001258592,0.002670692,0.00001139321,0.000005335201,0.000001102723],"genre_scores_gemma":[0.9929676,0.004271664,0.002361184,0.0001030994,0.0002021902,0.00006195681,8.446232e-7,0.0000282973,0.000003156493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3265825,"threshold_uncertainty_score":0.5820041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034116265050918,"score_gpt":0.3969424842495555,"score_spread":0.2935308577444637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}