{"id":"W2410894294","doi":"10.1016/j.ahj.2016.05.010","title":"Evaluating bococizumab, a monoclonal antibody to PCSK9, on lipid levels and clinical events in broad patient groups with and without prior cardiovascular events: Rationale and design of the Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Lipid Lowering and SPIRE Cardiovascular Outcomes Trials","year":2016,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Pfizer","keywords":"PCSK9; Medicine; Spire (mollusc); Placebo; Internal medicine; Residual risk; Statin; Cholesterol; Disease; Clinical trial; Cardiology; Virology; Lipoprotein; LDL receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0130607,0.001897474,0.003449945,0.0006622548,0.0008426275,0.001329028,0.001108631,0.002428787,0.003155375],"category_scores_gemma":[0.007564208,0.0008324316,0.004216142,0.0008762882,0.00154219,0.001029721,0.000791087,0.002903554,0.0005362158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009643243,"about_ca_system_score_gemma":0.002478543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006569937,"about_ca_topic_score_gemma":0.001652188,"domain_scores_codex":[0.9934723,0.004487311,0.0006641446,0.0005889797,0.0003761727,0.0004110633],"domain_scores_gemma":[0.9950935,0.001679451,0.001220062,0.0002913151,0.0006509795,0.00106467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9274917,0.008371297,0.009174735,0.002542,0.006881882,0.000146686,0.0001805341,0.00145977,0.007591072,0.0006828951,0.0009242047,0.03455309],"study_design_scores_gemma":[0.7495212,0.215098,0.01961623,0.0003139885,0.006192802,0.0001364146,0.00006624815,0.0006761044,0.002178566,0.0009418905,0.005216141,0.00004240193],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8805959,0.05096247,0.004275026,0.003196421,0.0009270017,0.04874951,0.002349396,0.00008557121,0.008858683],"genre_scores_gemma":[0.9415051,0.009176888,0.005481099,0.002369459,0.0009053285,0.03786932,0.001090875,0.00002068486,0.00158131],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.0130607,"threshold_uncertainty_score":0.06907243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034116265050918,"score_gpt":0.3969424842495555,"score_spread":0.2935308577444637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}