{"id":"W2410959361","doi":"10.1089/cell.2016.0009","title":"Exposure of Somatic Cells to Cytoplasm Extracts of Porcine Oocytes Induces Stem Cell-Like Colony Formation and Alters Expression of Pluripotency and Chromatin-Modifying Genes","year":2016,"lang":"en","type":"article","venue":"Cellular Reprogramming","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Biology; Homeobox protein NANOG; Reprogramming; Rex1; SOX2; Cell biology; Somatic cell; Chromatin; Molecular biology; Cellular differentiation; Histone; Gene expression; Stem cell; Cell; Embryonic stem cell; Gene; Induced pluripotent stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051467,0.0003333124,0.000213047,0.0001049195,0.0001009208,0.0002451974,0.0001157776,0.0002037984,0.001445993],"category_scores_gemma":[0.00009569082,0.000119066,0.000275418,0.00007308145,0.0001773754,0.0001354819,0.0001858823,0.0003951101,0.000263638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001282593,"about_ca_system_score_gemma":0.0001502623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003312688,"about_ca_topic_score_gemma":0.0006222365,"domain_scores_codex":[0.9999005,0.00001404966,0.00001147057,0.00002690384,0.00002329262,0.00002387912],"domain_scores_gemma":[0.9999284,0.00002074573,0.00002067071,0.000008684142,0.000007945591,0.00001359402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001355149,0.000002888421,0.00003249892,0.00001478424,0.000001215229,0.00001526422,0.000005043052,0.000004180032,0.9997495,0.00001207126,0.000004406766,0.0001446044],"study_design_scores_gemma":[0.000006469929,0.0002346384,0.00363622,0.000003787187,0.000007982258,0.0001290081,0.00002549499,0.00008323695,0.9940172,0.00001759316,0.001835854,0.000002369613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901559,0.001820711,0.004820676,0.0001201283,0.00005588605,0.00006519799,0.0004646788,0.00005508425,0.002441641],"genre_scores_gemma":[0.9893112,0.001533588,0.002880255,0.0001093862,0.00002393256,0.00008055584,0.001659794,0.00003629579,0.004364983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445993,"threshold_uncertainty_score":0.004837275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525063109676468,"score_gpt":0.2410958705709396,"score_spread":0.2258452394741749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}