{"id":"W2410959361","doi":"10.1089/cell.2016.0009","title":"Exposure of Somatic Cells to Cytoplasm Extracts of Porcine Oocytes Induces Stem Cell-Like Colony Formation and Alters Expression of Pluripotency and Chromatin-Modifying Genes","year":2016,"lang":"en","type":"article","venue":"Cellular Reprogramming","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Biology; Homeobox protein NANOG; Reprogramming; Rex1; SOX2; Cell biology; Somatic cell; Chromatin; Molecular biology; Cellular differentiation; Histone; Gene expression; Stem cell; Cell; Embryonic stem cell; Gene; Induced pluripotent stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004615658,0.0001881426,0.000332574,0.0001380775,0.00006202999,0.00001629972,0.0001729707,0.0001540952,0.000004180936],"category_scores_gemma":[0.0000390731,0.0001452747,0.00006737822,0.0001173201,0.0001345327,0.00002817232,0.0002530187,0.0000550266,9.931471e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001346294,"about_ca_system_score_gemma":0.00003906626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001763214,"about_ca_topic_score_gemma":0.000003076934,"domain_scores_codex":[0.9983735,0.00008521527,0.0005797638,0.0003909052,0.0002905461,0.000280085],"domain_scores_gemma":[0.9988055,0.00006420841,0.0004315523,0.0004191436,0.0001485924,0.0001309859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008709249,0.00007393491,0.001650056,0.001172804,0.00001940641,0.000004801377,0.000475159,0.00001903056,0.9576663,0.000001840333,0.00001024197,0.03881931],"study_design_scores_gemma":[0.0007242587,0.0005781774,0.0004587438,0.0004484789,0.00002473928,0.00001004422,0.0005583326,0.00006461803,0.9966778,0.00001037513,0.0002891368,0.0001553578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906654,0.004800236,0.003854461,0.00003272429,0.00005015472,0.0005427582,0.00001094484,0.000009491686,0.00003386588],"genre_scores_gemma":[0.9949614,0.0006433228,0.00414959,0.000004395522,0.00002689444,0.00002624171,0.00001584453,0.00002446486,0.0001478085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03901142,"threshold_uncertainty_score":0.5924132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525063109676468,"score_gpt":0.2410958705709396,"score_spread":0.2258452394741749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}