{"id":"W2410990138","doi":"10.1136/annrheumdis-2015-eular.2404","title":"THU0073 14-3-3ETA as a Novel RA Drug Target: Anti-14-3-3ETA Monoclonal Antibody Delays the Onset and Mitigates the Severity of Arthritis in CIA MICE","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; National Research Council Canada","funders":"","keywords":"Medicine; Dexamethasone; Monoclonal antibody; Arthritis; Internal medicine; Placebo; Biomarker; Rheumatoid arthritis; Immunology; In vivo; Drug; Pharmacology; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002435937,0.0007150706,0.0006469273,0.0009291707,0.0004331498,0.000524944,0.0005483117,0.0008672457,0.002520056],"category_scores_gemma":[0.0001236578,0.0003230454,0.0004739011,0.0003870827,0.000535153,0.0002691071,0.0001812599,0.002596313,0.0007676102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005708405,"about_ca_system_score_gemma":0.0008457526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001925838,"about_ca_topic_score_gemma":0.004578552,"domain_scores_codex":[0.9996958,0.0000409478,0.00002041697,0.00003769328,0.00008954242,0.0001157781],"domain_scores_gemma":[0.9998379,0.00001170059,0.00004182397,0.00001093624,0.00001480921,0.00008279133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009088363,0.0002133692,0.0001427133,0.00005063098,0.00001230236,0.00007526252,0.00001242686,0.0001430926,0.9956831,0.0002318866,0.0002592943,0.00226697],"study_design_scores_gemma":[0.000299813,0.001447896,0.002392585,0.00001188241,0.000045424,0.0002779089,0.00003353952,0.001174164,0.9902063,0.0001009863,0.003998256,0.0000111844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864128,0.003008506,0.004024697,0.000863983,0.0003120108,0.00008270816,0.0008785542,0.0005573992,0.003859423],"genre_scores_gemma":[0.9835565,0.00162626,0.004426538,0.000258911,0.00007381419,0.0001292889,0.0008085307,0.00008583608,0.00903431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002520056,"threshold_uncertainty_score":0.008430421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174235555666133,"score_gpt":0.3000014204084483,"score_spread":0.278259064851787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}