{"id":"W2410990138","doi":"10.1136/annrheumdis-2015-eular.2404","title":"THU0073 14-3-3ETA as a Novel RA Drug Target: Anti-14-3-3ETA Monoclonal Antibody Delays the Onset and Mitigates the Severity of Arthritis in CIA MICE","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; National Research Council Canada","funders":"","keywords":"Medicine; Dexamethasone; Monoclonal antibody; Arthritis; Internal medicine; Placebo; Biomarker; Rheumatoid arthritis; Immunology; In vivo; Drug; Pharmacology; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004970759,0.0002297157,0.000340967,0.00004624222,0.0001428375,0.00004888673,0.0006509916,0.00007876132,0.0000350375],"category_scores_gemma":[0.001348425,0.0001364585,0.0002237886,0.00017898,0.000549473,0.00002700686,0.000383835,0.0001555575,0.000007165439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007154664,"about_ca_system_score_gemma":0.0002381363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008193642,"about_ca_topic_score_gemma":0.0001716674,"domain_scores_codex":[0.9983268,0.0002823412,0.0005030553,0.0002879901,0.0003185397,0.0002813117],"domain_scores_gemma":[0.9983167,0.0002086234,0.0003673949,0.0007147898,0.000274144,0.0001183583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003055769,0.008234448,0.4533139,0.001792683,0.005337984,0.00003758231,0.011085,0.004752881,0.2490134,0.003077374,0.2359121,0.02438685],"study_design_scores_gemma":[0.00390635,0.0005389263,0.5205914,0.002517064,0.0003443332,0.0003750657,0.005253246,0.002719831,0.4363141,0.0183613,0.007929828,0.00114852],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845707,0.009807753,0.00005692403,0.004082226,0.0001587253,0.0005127801,0.000566112,0.00000782583,0.0002369652],"genre_scores_gemma":[0.9972892,0.001571127,0.0001915466,0.0005988076,0.00003681818,0.00004926396,0.00006791569,0.0000224387,0.0001729145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2279823,"threshold_uncertainty_score":0.5564615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174235555666133,"score_gpt":0.3000014204084483,"score_spread":0.278259064851787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}