{"id":"W2410997457","doi":"10.1152/physrev.00016.2015","title":"TRPV4: Molecular Conductor of a Diverse Orchestra","year":2016,"lang":"en","type":"review","venue":"Physiological Reviews","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":400,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; KU Leuven; Imperial College London; Queen's University Belfast; University of Birmingham; Queen's University; British Heart Foundation","keywords":"Transient receptor potential channel; TRPV4; Ion channel; Ionotropic effect; TRPC1; Agonist; Cell biology; Mechanosensation; Receptor; Chemistry; Biophysics; Neuroscience; Voltage-dependent calcium channel; Stimulation; Biology; Calcium; Biochemistry; Glutamate receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003423762,0.0008744206,0.0008565068,0.001466132,0.000302507,0.001176089,0.000984353,0.001105581,0.003840292],"category_scores_gemma":[0.0003617035,0.0002122874,0.000445888,0.0009195712,0.0006694589,0.001656046,0.0008408594,0.001915278,0.004203715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007575188,"about_ca_system_score_gemma":0.0009269587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005097441,"about_ca_topic_score_gemma":0.0005267494,"domain_scores_codex":[0.9998519,0.00001830668,0.00001693508,0.00003620884,0.00004856622,0.00002803379],"domain_scores_gemma":[0.9999053,0.00002340036,0.00001667033,0.000004094215,0.00003348413,0.00001694996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001555346,0.00004602797,0.0002734645,0.01156517,0.00006835484,0.0003217083,0.0001178983,0.0003803711,0.01530139,0.01938721,0.06171156,0.8906714],"study_design_scores_gemma":[0.000006903612,0.00004498532,0.0003343856,0.00065753,0.00003022643,0.001026669,0.00004472472,0.00005889335,0.001484306,0.002498574,0.9937976,0.00001507803],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002977647,0.9942152,0.0006791,0.0007477556,0.0007525079,0.000009407209,0.00005540911,0.00004140846,0.003201451],"genre_scores_gemma":[0.002909258,0.9921877,0.0003936684,0.0005164379,0.0004603868,0.0000146872,0.0001194945,0.000007709686,0.003390664],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003840292,"threshold_uncertainty_score":0.01284707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4099799449906391,"score_gpt":0.4311118517766001,"score_spread":0.021131906785961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}