{"id":"W2411039126","doi":"10.3390/cancers8060055","title":"RASSF1A Site-Specific Methylation Hotspots in Cancer and Correlation with RASSF1C and MOAP-1","year":2016,"lang":"en","type":"article","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Calgary; University of Alberta","funders":"Cancer Research UK","keywords":"CpG site; Epigenetics; Methylation; Gene silencing; Biology; DNA methylation; Cancer research; Molecular biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148281,0.0000967134,0.00008918616,0.00004959408,0.00003589905,0.00001398794,0.000027502,0.00009062716,0.00001490471],"category_scores_gemma":[0.00001668368,0.0000705515,0.00001116545,0.00007245037,0.00006933128,0.000007118281,0.00001914943,0.00003651484,0.000001111463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001070387,"about_ca_system_score_gemma":0.00007770405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001460084,"about_ca_topic_score_gemma":0.0007803343,"domain_scores_codex":[0.9993907,0.00002864686,0.0001111859,0.0002691274,0.00007332902,0.0001270306],"domain_scores_gemma":[0.999707,0.00002141308,0.00006188494,0.0001130118,0.00004360154,0.00005310629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001753538,0.000003768832,0.1697422,0.000009312113,0.00001175032,9.836135e-7,0.0001102368,0.0009578239,0.7747245,0.00006756024,0.00008954413,0.05410691],"study_design_scores_gemma":[0.00369795,0.0005613018,0.6213093,0.0001493201,0.00003200086,0.000002990939,0.0001016113,0.0009722791,0.3335209,0.0004741842,0.03863357,0.000544686],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869912,0.007717751,0.00462215,0.000153795,0.00008247279,0.0001418875,0.00001264106,0.000005215289,0.0002729218],"genre_scores_gemma":[0.9908127,0.00839169,0.0002882986,0.00003356642,0.0000832303,0.00002877942,0.00001538752,0.00001387211,0.0003324747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.451567,"threshold_uncertainty_score":0.2877007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208206117377944,"score_gpt":0.2517089388552666,"score_spread":0.2396268776814871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}