{"id":"W2411039126","doi":"10.3390/cancers8060055","title":"RASSF1A Site-Specific Methylation Hotspots in Cancer and Correlation with RASSF1C and MOAP-1","year":2016,"lang":"en","type":"article","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Calgary; University of Alberta","funders":"Cancer Research UK","keywords":"CpG site; Epigenetics; Methylation; Gene silencing; Biology; DNA methylation; Cancer research; Molecular biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241766,0.0001382263,0.0001827741,0.0006782011,0.0001623825,0.0001895731,0.0001231951,0.0001679433,0.001347236],"category_scores_gemma":[0.0003292246,0.0001934176,0.0001241381,0.000459602,0.0001922601,0.00009435225,0.0001475071,0.0002589481,0.0002503478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002058009,"about_ca_system_score_gemma":0.0001570863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001809594,"about_ca_topic_score_gemma":0.001943604,"domain_scores_codex":[0.9998939,0.00001407023,0.000007641162,0.00003303286,0.00002777953,0.00002354387],"domain_scores_gemma":[0.9997392,0.00003923347,0.0001136463,0.00002078632,0.00004266387,0.00004438973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007946264,0.00003662913,0.2259338,0.000133345,0.000101267,0.0004374817,0.0002105556,0.0003524703,0.756512,0.0002373806,0.0001994933,0.01505096],"study_design_scores_gemma":[0.000006811952,0.0001057682,0.9246528,0.000006447747,0.00004462526,0.001650068,0.00009290013,0.0007679341,0.07076604,0.0001716813,0.001724359,0.00001053923],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948303,0.00315579,0.0009326915,0.00005513278,0.000005831782,0.000009126258,0.0002887638,0.00005624506,0.0006661407],"genre_scores_gemma":[0.9982659,0.0005116728,0.0004625064,0.000009834551,0.000003408162,0.000006121659,0.0001948069,0.000003616667,0.0005421054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001809594,"threshold_uncertainty_score":0.004507005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208206117377944,"score_gpt":0.2517089388552666,"score_spread":0.2396268776814871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}