{"id":"W2411105085","doi":"10.1016/s0140-6736(16)30169-6","title":"Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial","year":2016,"lang":"en","type":"article","venue":"The Lancet","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; McGill University Health Centre; Canadian Blood Services; NeuroRx Research (Canada); University of Toronto; Montreal Neurological Institute and Hospital; University of Ottawa; McGill University; Ottawa Hospital","funders":"Multiple Sclerosis Scientific Research Foundation","keywords":"Medicine; Multiple sclerosis; Expanded Disability Status Scale; Cyclophosphamide; Transplantation; Busulfan; Filgrastim; Internal medicine; Immunosuppression; Hematopoietic stem cell transplantation; Surgery; Autologous stem-cell transplantation; Oncology; Gastroenterology; Chemotherapy; Granulocyte colony-stimulating factor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003051384,0.002561992,0.003922993,0.0005745479,0.0006938233,0.001366278,0.001252929,0.002722742,0.004439218],"category_scores_gemma":[0.001935749,0.0006553271,0.003031732,0.0006639007,0.00169683,0.001381325,0.0006844208,0.003823783,0.0008549816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001156715,"about_ca_system_score_gemma":0.001404904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001387299,"about_ca_topic_score_gemma":0.002242312,"domain_scores_codex":[0.9986994,0.0007592644,0.00005858667,0.000200753,0.00008603178,0.0001958232],"domain_scores_gemma":[0.9987431,0.0003407539,0.0002836533,0.0001551099,0.00007055532,0.00040684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.978452,0.003674976,0.0004565768,0.0004228343,0.001636379,0.00003893453,0.00005505571,0.0002891886,0.002437241,0.0001221715,0.0006863065,0.01172855],"study_design_scores_gemma":[0.9574949,0.03939068,0.001474943,0.00002562776,0.0006382518,0.00003376547,0.00001857619,0.0001155838,0.0002404641,0.000171884,0.0003820851,0.00001322882],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848546,0.008275623,0.0007673811,0.001500254,0.0005708432,0.001725488,0.0008241281,0.00009779826,0.001383947],"genre_scores_gemma":[0.9848191,0.003784477,0.001671873,0.001816451,0.0006255357,0.003463719,0.001029527,0.00003369166,0.002755718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004439218,"threshold_uncertainty_score":0.01613748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1086055346947618,"score_gpt":0.3271631964805181,"score_spread":0.2185576617857563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}