{"id":"W2411164352","doi":"10.1007/978-1-61779-197-0_9","title":"Array-Based Synthetic Genetic Screens to Map Bacterial Pathways and Functional Networks in Escherichia coli","year":2011,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Epistasis; Genetic Fitness; Mutant; Biology; Gene; Phenotype; Genetic screen; Genetics; Computational biology; Function (biology); Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003368216,0.0008935193,0.0005170457,0.001257555,0.000249407,0.000484286,0.0005551472,0.0004303575,0.00180116],"category_scores_gemma":[0.0004441341,0.0004314637,0.0005745663,0.001019285,0.0003524316,0.0002248962,0.0006634617,0.0006871108,0.0008939706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005785241,"about_ca_system_score_gemma":0.0002852053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082467,"about_ca_topic_score_gemma":0.001998651,"domain_scores_codex":[0.9995205,0.0001466768,0.00005535416,0.00008669734,0.0001394917,0.00005119013],"domain_scores_gemma":[0.9996397,0.0001692545,0.00007624319,0.00004248771,0.0000244647,0.00004774317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001412283,0.00008605076,0.0005082575,0.0001039445,0.00003119594,0.0001129553,0.0000197166,0.002230226,0.991949,0.0007050938,0.0001200631,0.003992341],"study_design_scores_gemma":[0.0001177449,0.0008917629,0.01096946,0.00003898414,0.0001388754,0.0005981941,0.00009218894,0.02915351,0.945851,0.001594727,0.01050029,0.00005333808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7612908,0.003129524,0.2131252,0.0003259414,0.0001141469,0.0006524128,0.008802895,0.002529174,0.01002982],"genre_scores_gemma":[0.860981,0.002698542,0.1248124,0.000294822,0.00001336158,0.0008029836,0.005704788,0.0002595995,0.004432607],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00180116,"threshold_uncertainty_score":0.006025493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311712559307722,"score_gpt":0.2822760303631986,"score_spread":0.2591589047701214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}