{"id":"W2411172204","doi":"10.1021/acs.biochem.5b00903","title":"Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Chemistry; Electron paramagnetic resonance; Pregnenolone; Photochemistry; Ferric; Ternary complex; Hydroxylation; Hyperfine structure; Ternary operation; Electron nuclear double resonance; Stereochemistry; Steroid; Inorganic chemistry; Organic chemistry; Nuclear magnetic resonance; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008688567,0.0003141444,0.0003090368,0.00004312291,0.0003388048,0.00007424378,0.0004720356,0.0001867187,0.00005383881],"category_scores_gemma":[0.0003540891,0.0002132585,0.00005262761,0.000262146,0.0005369762,0.0001252276,0.0003390556,0.0006353845,0.00002033816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064326,"about_ca_system_score_gemma":0.000125765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004241091,"about_ca_topic_score_gemma":0.00002119334,"domain_scores_codex":[0.9981606,0.0003420768,0.0002975639,0.0004903392,0.000272206,0.0004372283],"domain_scores_gemma":[0.9983868,0.0006055489,0.0001915381,0.0003589011,0.0001688577,0.0002883657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000891283,0.0003189611,0.0123708,0.0001770351,0.0006188136,0.00003232749,0.02210861,0.0005176668,0.8090966,0.00002044557,0.147554,0.006293405],"study_design_scores_gemma":[0.00135417,0.00004123127,0.001642514,0.00009916967,0.0001820374,0.00005581991,0.007157546,0.0004678462,0.9355891,0.000109243,0.05300468,0.0002966481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9466322,0.03997794,0.000007537528,0.01145249,0.0007666557,0.0005105096,0.00016256,0.00003168527,0.0004584215],"genre_scores_gemma":[0.9877697,0.006573276,0.00002301064,0.003715786,0.0003789406,0.0001336933,0.00001181088,0.00002110689,0.001372689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1264925,"threshold_uncertainty_score":0.869643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2901483038949986,"score_gpt":0.447085334777917,"score_spread":0.1569370308829183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}