{"id":"W2411198784","doi":"10.2741/4416","title":"New genomic landscapes and therapeutic targets for biliary tract cancers","year":2015,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"","keywords":"KRAS; Cancer research; PI3K/AKT/mTOR pathway; Biliary tract; Medicine; ARID1A; Discovery and development of mTOR inhibitors; Intrahepatic Cholangiocarcinoma; Receptor tyrosine kinase; Targeted therapy; IDH1; P110α; Bioinformatics; Oncology; Biology; Internal medicine; Signal transduction; Cancer; Receptor; Gene; Mutation; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003157099,0.0003273562,0.001355629,0.0003060852,0.00007346589,0.00003182472,0.0002288693,0.0001680733,0.000006160031],"category_scores_gemma":[0.00004394671,0.0002367951,0.0001959897,0.0003811918,0.000143634,0.00005802682,0.00006124333,0.0002182306,0.000002243763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005343496,"about_ca_system_score_gemma":0.001609712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000977508,"about_ca_topic_score_gemma":0.00004495545,"domain_scores_codex":[0.9984283,0.00003133693,0.0003293856,0.0006010046,0.0002090276,0.0004008773],"domain_scores_gemma":[0.999298,0.00005023447,0.0001399911,0.0002621339,0.00003849,0.0002112034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002493261,0.00001533554,0.002840996,0.002330837,0.00006700535,0.00001090355,0.0003639925,3.115641e-7,0.000001576055,0.000005128262,0.03640264,0.9579363],"study_design_scores_gemma":[0.0006524045,0.0001790948,0.001485936,0.001538491,0.0004787997,0.00004589818,0.0001620995,0.00005050369,9.157833e-7,0.0001135169,0.9950215,0.0002708675],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003809269,0.9961883,0.0005942149,0.0001528402,0.001488262,0.001178727,0.00005187036,0.00002584348,0.0002818479],"genre_scores_gemma":[0.0001102141,0.9926246,0.005971496,0.0001692065,0.0002856231,0.0001056242,0.00002171403,0.00003168506,0.0006798321],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9586188,"threshold_uncertainty_score":0.9656223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05087616133280399,"score_gpt":0.3301844256607549,"score_spread":0.2793082643279509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}