{"id":"W2411198784","doi":"10.2741/4416","title":"New genomic landscapes and therapeutic targets for biliary tract cancers","year":2015,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"","keywords":"KRAS; Cancer research; PI3K/AKT/mTOR pathway; Biliary tract; Medicine; ARID1A; Discovery and development of mTOR inhibitors; Intrahepatic Cholangiocarcinoma; Receptor tyrosine kinase; Targeted therapy; IDH1; P110α; Bioinformatics; Oncology; Biology; Internal medicine; Signal transduction; Cancer; Receptor; Gene; Mutation; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004252538,0.0005881307,0.001117446,0.002185694,0.0002117006,0.0007446756,0.0005580609,0.0008647479,0.002851483],"category_scores_gemma":[0.0005135583,0.0002433542,0.0004462658,0.001498845,0.0004228748,0.001113665,0.0005858911,0.001431095,0.001180389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005609663,"about_ca_system_score_gemma":0.0005885673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006678674,"about_ca_topic_score_gemma":0.001855275,"domain_scores_codex":[0.9998907,0.00002504257,0.00001817662,0.00002057456,0.00003350447,0.00001205847],"domain_scores_gemma":[0.9998382,0.00008231222,0.00002379521,0.000004551324,0.0000375326,0.00001352262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007701171,0.00006938345,0.0002355161,0.01493429,0.0001095132,0.0003695938,0.00006464215,0.0004783684,0.002028497,0.005781271,0.02142789,0.9544241],"study_design_scores_gemma":[0.00002945541,0.0001187914,0.001075852,0.004117933,0.0001468842,0.001862852,0.00008059411,0.0001388415,0.0005925272,0.003452786,0.9883643,0.00001906564],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009737456,0.9990836,0.00006343418,0.00022781,0.00005721283,0.000002244709,0.000008842803,0.000003561239,0.00045578],"genre_scores_gemma":[0.0009439451,0.9982451,0.0001293251,0.0002389052,0.00008619307,0.000004889549,0.00002076761,9.460535e-7,0.0003299133],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002851483,"threshold_uncertainty_score":0.009539187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05087616133280399,"score_gpt":0.3301844256607549,"score_spread":0.2793082643279509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}