{"id":"W2411303485","doi":"10.1021/cb5009487","title":"Colloidal Aggregation and the <i>in Vitro</i> Activity of Traditional Chinese Medicines","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Traditional Chinese Medicine Analysis","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"In vitro; Chemistry; Small molecule; Biochemistry; Enzyme; Malate dehydrogenase; IC50; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004270614,0.0001204621,0.0004961712,0.00009717853,0.00001479899,0.000001749176,0.00007334683,0.0001101114,0.00001502798],"category_scores_gemma":[0.00160363,0.00006396163,0.00006749245,0.0003345616,0.0007787989,0.00004110114,0.00002606995,0.0002122476,0.000002075509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000401999,"about_ca_system_score_gemma":0.00008692315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001001578,"about_ca_topic_score_gemma":0.000007212116,"domain_scores_codex":[0.9991381,0.00008372341,0.0002618316,0.0001915751,0.0001993562,0.0001254648],"domain_scores_gemma":[0.9987391,0.0008077482,0.00009480154,0.0001420156,0.0001034659,0.0001128317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003395125,0.0002672602,0.03270828,0.00004065473,0.0001163241,0.00001053303,0.0002805242,0.000001389697,0.9570607,0.001797791,0.0008625529,0.003458849],"study_design_scores_gemma":[0.05436671,0.0009186378,0.1254649,0.0001685155,0.0007414293,0.0009236471,0.0002730917,0.002445947,0.7085391,0.1046227,0.001069534,0.0004657556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833152,0.0004247999,0.00004326711,0.0149634,0.00006635944,0.000171603,0.0000251707,0.00001376125,0.0009763967],"genre_scores_gemma":[0.9981347,0.00003674536,0.0001995245,0.0009881629,0.0003853358,0.00002532706,0.0002050668,0.000006450249,0.00001870156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2485216,"threshold_uncertainty_score":0.2869517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02434355483412067,"score_gpt":0.2782192406767851,"score_spread":0.2538756858426644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}