{"id":"W2411341413","doi":"10.1385/1-59259-949-4:325","title":"Assay and Purification of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase and Isozyme Separation","year":2005,"lang":"en","type":"article","venue":"Humana Press eBooks","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Calmodulin; Cyclic nucleotide phosphodiesterase; Phosphodiesterase; Guanosine; Cyclic nucleotide; Cyclic guanosine monophosphate; PDE10A; Isozyme; Second messenger system; Nucleotide; Intracellular; Enzyme; Biochemistry; Adenosine; Subcellular localization; Phosphodiesterase 3; Cyclic adenosine monophosphate; Guanosine monophosphate; Chemistry; Biology; Gene; Receptor; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005720292,0.001233333,0.001315387,0.001356328,0.0005925809,0.0005410951,0.001005997,0.0006550121,0.002375035],"category_scores_gemma":[0.0008405285,0.0004991971,0.0006878666,0.001059005,0.0004019616,0.000435928,0.0006328718,0.002230999,0.003890069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000396986,"about_ca_system_score_gemma":0.0006421409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001802274,"about_ca_topic_score_gemma":0.002418171,"domain_scores_codex":[0.9992266,0.00006103408,0.00007174228,0.0001979263,0.0002663491,0.0001764578],"domain_scores_gemma":[0.9995695,0.00006859039,0.00003884255,0.00006328752,0.0001472556,0.0001125087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007361612,0.0001481096,0.0004061812,0.0001689724,0.0000149763,0.0001003351,0.00006528311,0.00006508786,0.9880235,0.0003324215,0.0004874455,0.01011418],"study_design_scores_gemma":[0.0001457798,0.0005741835,0.01882684,0.0001149469,0.0000949902,0.0008957374,0.00009038607,0.002924521,0.8972419,0.0009833511,0.07806224,0.0000450746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4916218,0.0404578,0.4173063,0.00235297,0.001947502,0.005131373,0.009427939,0.003169519,0.0285848],"genre_scores_gemma":[0.42317,0.02225355,0.4378974,0.001463412,0.0008854584,0.005100455,0.06182519,0.0009267789,0.04647766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002375035,"threshold_uncertainty_score":0.007945299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059404316222994,"score_gpt":0.2700808703783149,"score_spread":0.2494868272160849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}