{"id":"W2411343638","doi":"10.1016/j.str.2016.05.002","title":"Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone","year":2016,"lang":"en","type":"article","venue":"Structure","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto; Canada Foundation for Innovation","keywords":"Chaperone (clinical); Biophysics; Chemistry; AAA proteins; Amyloid (mycology); Escherichia coli; ATPase; Force spectroscopy; Biochemistry; Cell biology; Nuclear magnetic resonance spectroscopy; Biology; Stereochemistry; Enzyme; Molecule; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004771797,0.0004832107,0.0003935765,0.0002796201,0.0007364759,0.000603819,0.0005350036,0.0005814393,0.0005612738],"category_scores_gemma":[0.000399063,0.0002300404,0.0003302771,0.0001147286,0.0005000777,0.0007800615,0.0005001673,0.0007823738,0.0003985302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006071705,"about_ca_system_score_gemma":0.0003287832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003458378,"about_ca_topic_score_gemma":0.0001632265,"domain_scores_codex":[0.9998839,0.00002230904,0.000006866299,0.00002434867,0.0000285078,0.00003400402],"domain_scores_gemma":[0.9997615,0.00005340355,0.00003870712,0.00004090284,0.00004588806,0.00005959415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005222324,0.0002050001,0.002531508,0.0001905586,0.0000429142,0.001859352,0.0002175459,0.00505938,0.950087,0.02977427,0.001301781,0.00820846],"study_design_scores_gemma":[0.00009480862,0.0003793582,0.004900193,0.00003716181,0.00005119304,0.002640411,0.0002162749,0.08479918,0.8787486,0.02389719,0.004173161,0.0000624368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973407,0.00278503,0.01811959,0.0009515763,0.0001440466,0.00004540511,0.000104948,0.0003194233,0.004123054],"genre_scores_gemma":[0.9969838,0.0005672105,0.001392476,0.00005561108,0.00001588935,0.00001536343,0.00005310091,0.00001272078,0.000903687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007364759,"threshold_uncertainty_score":0.004405379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003820788535542825,"score_gpt":0.201792360144428,"score_spread":0.1979715716088851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}