{"id":"W2411456697","doi":"10.1038/srep16803","title":"Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Human Genome Research Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Regione Toscana; Associazione Italiana per la Ricerca sul Cancro","keywords":"Cohesin; Establishment of sister chromatid cohesion; Biology; Genetics; Cornelia de Lange Syndrome; RNA polymerase II; Gene; Transcriptional regulation; Regulation of gene expression; Transcription (linguistics); Gene expression; Cell biology; Promoter; Chromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007494857,0.0004748443,0.0002538914,0.000597199,0.0001233192,0.000213754,0.000121442,0.0003058783,0.0008716476],"category_scores_gemma":[0.000176808,0.0001948906,0.0002981918,0.0002730805,0.0002489884,0.00008410648,0.0001944742,0.0002734387,0.0001896944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000237335,"about_ca_system_score_gemma":0.0001327601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159237,"about_ca_topic_score_gemma":0.001493378,"domain_scores_codex":[0.999869,0.00001751456,0.00001662828,0.0000442532,0.00003793131,0.00001468121],"domain_scores_gemma":[0.999861,0.00003741027,0.00005121343,0.000008141826,0.000008341169,0.00003385999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001058429,0.00001368336,0.002952738,0.00002398968,0.00002021093,0.0008525792,0.0000247267,0.0001365064,0.9946406,0.00004034897,0.00004138685,0.001147425],"study_design_scores_gemma":[0.00007660385,0.0002790944,0.3006389,0.00003578936,0.0001880567,0.0107274,0.0001654154,0.004313253,0.6801966,0.0004003122,0.002931989,0.00004651627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980387,0.0005946026,0.0008211035,0.0000325094,0.00001297228,0.000004806061,0.0002590822,0.00005301377,0.0001832239],"genre_scores_gemma":[0.9987795,0.0002300589,0.0004341409,0.00004528194,0.000003750875,0.000005867962,0.000179735,0.00001951602,0.000302028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159237,"threshold_uncertainty_score":0.002915978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009748499147654948,"score_gpt":0.2234400664413487,"score_spread":0.2136915672936938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}