{"id":"W2411587754","doi":"10.1080/15284336.2016.1184827","title":"Can Probiotics Reduce Inflammation and Enhance Gut Immune Health in People Living with HIV: Study Designs for the Probiotic Visbiome for Inflammation and Translocation (PROOV IT) Pilot Trials","year":2016,"lang":"en","type":"article","venue":"HIV Clinical Trials","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic; University of Toronto; Public Health Ontario; University Health Network","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"Medicine; Cart; Immune system; Inflammation; Systemic inflammation; Immunology; Tolerability; Probiotic; Population; Placebo; Gut flora; Internal medicine; Adverse effect; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02318679,0.000229071,0.0009851016,0.00007371609,0.0002203595,0.00006726289,0.0001393403,0.0001800341,0.000002995938],"category_scores_gemma":[0.006936357,0.0001328488,0.0001142999,0.0001187841,0.0001079411,0.00001913865,0.00003672383,0.00010026,9.334257e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004622526,"about_ca_system_score_gemma":0.000557796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003039076,"about_ca_topic_score_gemma":0.001286965,"domain_scores_codex":[0.9947914,0.001906508,0.00230696,0.0005614181,0.00009370383,0.0003400314],"domain_scores_gemma":[0.9942526,0.004060485,0.001069311,0.0003371944,0.000174532,0.0001059383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004102728,0.0003662001,0.002252068,0.0004112347,0.0001747079,1.165249e-7,0.001174123,0.00002088612,0.9204911,0.00009622347,0.0004123639,0.07049826],"study_design_scores_gemma":[0.1021544,0.0635921,0.3655159,0.005005099,0.001416357,0.00003856179,0.004205846,0.001035512,0.4445686,0.001376189,0.008532302,0.002559047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9163924,0.0006428055,0.04661841,0.02287602,0.0001855991,0.01313952,0.0001254828,0.00001742062,0.00000234507],"genre_scores_gemma":[0.9939522,0.001821337,0.002652666,0.0001113117,0.0006151797,0.0005710272,0.00009125823,0.00003222158,0.0001528195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4759225,"threshold_uncertainty_score":0.8303968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1655538968730954,"score_gpt":0.4415779428807052,"score_spread":0.2760240460076098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}