{"id":"W2411587754","doi":"10.1080/15284336.2016.1184827","title":"Can Probiotics Reduce Inflammation and Enhance Gut Immune Health in People Living with HIV: Study Designs for the Probiotic Visbiome for Inflammation and Translocation (PROOV IT) Pilot Trials","year":2016,"lang":"en","type":"article","venue":"HIV Clinical Trials","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic; University of Toronto; Public Health Ontario; University Health Network","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"Medicine; Cart; Immune system; Inflammation; Systemic inflammation; Immunology; Tolerability; Probiotic; Population; Placebo; Gut flora; Internal medicine; Adverse effect; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01269448,0.002245845,0.002999831,0.0005333059,0.0009553868,0.001465695,0.001299967,0.004297161,0.005772871],"category_scores_gemma":[0.01142367,0.001041998,0.003800991,0.0006447979,0.001532141,0.001804593,0.00102447,0.002757852,0.0007731933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006177974,"about_ca_system_score_gemma":0.001879301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008919303,"about_ca_topic_score_gemma":0.001660941,"domain_scores_codex":[0.9929307,0.00545342,0.0004753961,0.0003950501,0.0003201437,0.0004253467],"domain_scores_gemma":[0.9935901,0.002433987,0.001755193,0.0006191225,0.0005661162,0.001035359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9662171,0.01528142,0.001134707,0.001110176,0.002335537,0.0000249805,0.00009652848,0.0002068219,0.001512583,0.0002048972,0.0003353397,0.01153989],"study_design_scores_gemma":[0.6251522,0.3678679,0.00236397,0.0001862444,0.002172176,0.00001608586,0.00005566357,0.0001789893,0.0005675448,0.000341005,0.001077545,0.00002059375],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9176172,0.01410518,0.003140828,0.002646879,0.00217266,0.05516075,0.001450824,0.00009182534,0.003613797],"genre_scores_gemma":[0.9018471,0.007013537,0.008406635,0.00365536,0.002088366,0.07236416,0.0009170729,0.00003020195,0.003677609],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01269448,"threshold_uncertainty_score":0.06713563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1655538968730954,"score_gpt":0.4415779428807052,"score_spread":0.2760240460076098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}