{"id":"W2411709723","doi":"10.1038/ncomms10023","title":"Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function","year":2016,"lang":"en","type":"review","venue":"Nature Communications","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":536,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; University of Ottawa","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Human Genome Research Institute; Economic and Social Research Council; British Heart Foundation; National Cancer Institute; National Institutes of Health; Lundbeckfonden; National Institute for Health and Care Research; National Institute of General Medical Sciences; Medical Research Council","keywords":"Computational biology; Function (biology); Biology; Biological pathway; Evolutionary biology; Genetics; Bioinformatics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001300142,0.0002540329,0.0004202407,0.00005645583,0.0003659643,0.00002079599,0.0005338785,0.00160521,0.00001021749],"category_scores_gemma":[0.0001812844,0.0001617727,0.0002983608,0.0001085495,0.0001365068,0.000002596438,0.0003772445,0.0004684442,0.00002873593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000101327,"about_ca_system_score_gemma":0.0002228904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001874234,"about_ca_topic_score_gemma":0.00001778608,"domain_scores_codex":[0.9988506,0.0001788302,0.0003249739,0.0003673393,0.0000760707,0.0002022119],"domain_scores_gemma":[0.9983159,0.0001494156,0.0003032814,0.000976324,0.0001375146,0.0001175406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000792673,0.0003099994,0.000134162,0.00260125,0.001696276,0.000001622688,0.00004711455,0.000001700387,0.008432292,0.00594579,0.3435957,0.6371549],"study_design_scores_gemma":[0.0002018577,0.0001093142,0.00003901579,0.0004022146,0.0003418209,0.000008351627,0.000001781909,0.000001904066,0.00008237937,0.0001294142,0.9984452,0.0002367345],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002744599,0.9960899,0.000112848,0.0005810926,0.0002612808,0.0005654384,0.0009264171,0.00002368402,0.001411915],"genre_scores_gemma":[0.0008705027,0.9918652,0.0009255673,0.000310903,0.0002403028,0.0002619672,0.003996304,0.00003587262,0.001493415],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6548495,"threshold_uncertainty_score":0.9996909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02681937628848216,"score_gpt":0.2926728031691634,"score_spread":0.2658534268806813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}