{"id":"W2411709723","doi":"10.1038/ncomms10023","title":"Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function","year":2016,"lang":"en","type":"review","venue":"Nature Communications","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":536,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; University of Ottawa","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Human Genome Research Institute; Economic and Social Research Council; British Heart Foundation; National Cancer Institute; National Institutes of Health; Lundbeckfonden; National Institute for Health and Care Research; National Institute of General Medical Sciences; Medical Research Council","keywords":"Computational biology; Function (biology); Biology; Biological pathway; Evolutionary biology; Genetics; Bioinformatics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008513567,0.0008135724,0.001465756,0.002860616,0.0001536358,0.0008279174,0.0008611681,0.0008127015,0.002488358],"category_scores_gemma":[0.001008346,0.0002299218,0.0007915244,0.002658252,0.0004456709,0.00072305,0.0005072532,0.0007869341,0.0009603373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007744557,"about_ca_system_score_gemma":0.001216538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001717911,"about_ca_topic_score_gemma":0.003390587,"domain_scores_codex":[0.9997416,0.00005036642,0.00003688004,0.00006969675,0.00007297292,0.00002853331],"domain_scores_gemma":[0.9994901,0.0002669845,0.00009412551,0.00001568081,0.00009892153,0.00003409302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002381068,0.00002358548,0.004284404,0.02155162,0.0008781545,0.0005352345,0.00007155019,0.0005312389,0.003458092,0.002939859,0.01329465,0.9521934],"study_design_scores_gemma":[0.00007603529,0.0002390382,0.03570233,0.01049812,0.003289351,0.006997025,0.0001874594,0.0002441287,0.002732021,0.004671225,0.9352823,0.00008108408],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003982252,0.9983518,0.0001924535,0.0002666642,0.00005693999,0.000003169951,0.00006397363,0.000007638725,0.0006590906],"genre_scores_gemma":[0.003824692,0.9950046,0.0003449477,0.0001656061,0.00009387894,0.000005777277,0.0001093326,0.000002559969,0.0004486199],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002860616,"threshold_uncertainty_score":0.008324325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02681937628848216,"score_gpt":0.2926728031691634,"score_spread":0.2658534268806813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}