{"id":"W2411836947","doi":"10.1136/annrheumdis-2015-eular.2265","title":"THU0425 Secukinumab Improves Signs and Symptoms of Active Psoriatic Arthritis in a Phase 3 Randomized, Multicenter, Double-Blind, Placebo-Controlled Study Using a Subcutaneous Dosing Regimen (Future 2)","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Medicine; Secukinumab; Psoriatic arthritis; Clinical endpoint; Placebo; Placebo-controlled study; Internal medicine; Psoriasis Area and Severity Index; Regimen; Dactylitis; Dosing; Enthesitis; Randomized controlled trial; Gastroenterology; Rheumatoid arthritis; Psoriasis; Immunology; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001771431,0.001968337,0.003327531,0.0007917484,0.0007350617,0.001086142,0.0009892631,0.002165074,0.007231195],"category_scores_gemma":[0.0009916655,0.0009610229,0.002314189,0.0005198073,0.001321675,0.001190667,0.0003127884,0.002917235,0.001133456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004956687,"about_ca_system_score_gemma":0.001012997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000991129,"about_ca_topic_score_gemma":0.002414524,"domain_scores_codex":[0.999408,0.0002578818,0.00003807742,0.0001082786,0.00005069111,0.0001370313],"domain_scores_gemma":[0.9994804,0.0001095445,0.0001052563,0.00004908917,0.00004728253,0.0002084773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9394251,0.0231689,0.0005878364,0.0006754274,0.0009003586,0.00006315932,0.00006687541,0.0003753371,0.01139998,0.0000915918,0.001044412,0.02220115],"study_design_scores_gemma":[0.8428211,0.153272,0.001879213,0.00002127803,0.0003144954,0.00003640455,0.00002329484,0.0003305658,0.0009282664,0.00005664506,0.0002962518,0.00002053409],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892278,0.003004684,0.0009529894,0.0004619257,0.0004984693,0.003270915,0.0009191866,0.000285905,0.001378204],"genre_scores_gemma":[0.9853122,0.002558831,0.002663555,0.001118554,0.0004895686,0.00292606,0.001107059,0.00004689348,0.003777242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007231195,"threshold_uncertainty_score":0.02419078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03839619751798624,"score_gpt":0.3107881325951577,"score_spread":0.2723919350771715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}