{"id":"W2411962548","doi":"10.1186/s13059-016-0976-2","title":"Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer’s disease neurons","year":2016,"lang":"en","type":"article","venue":"Genome biology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"European Research Council; Universitair Medisch Centrum Groningen; KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministry of Earth Sciences; Rijksuniversiteit Groningen","keywords":"Aneuploidy; Biology; Neurodegeneration; Chromosome 21; Disease; Alzheimer's disease; Chromosome; Human genetics; Genetics; Neuroscience; Pathology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002375899,0.0002280871,0.0002583895,0.00007083535,0.00008962097,0.00001755444,0.0002526273,0.0001873226,0.00001449873],"category_scores_gemma":[0.0001102099,0.0001849977,0.00008725061,0.00005905187,0.0001902943,0.0000122074,0.0001180939,0.0000762843,0.00001854373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003890388,"about_ca_system_score_gemma":0.00009130427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004059106,"about_ca_topic_score_gemma":0.0000711692,"domain_scores_codex":[0.9984294,0.0001211794,0.0003306393,0.000586285,0.00004898271,0.000483519],"domain_scores_gemma":[0.9991894,0.0001006614,0.00009820267,0.0003591295,0.00006854337,0.0001840597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004206818,0.00005694093,0.0264354,0.00003664209,0.00001691415,0.000006292022,0.00003474209,0.0000102341,0.9717374,0.00001887293,0.00003065589,0.001195222],"study_design_scores_gemma":[0.01198667,0.01286978,0.2059617,0.0003562314,0.0005168424,0.0001197251,0.0001181467,0.0002671701,0.4373777,0.001850695,0.324703,0.003872315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904152,0.007025673,0.001066961,0.0004078751,0.0002185191,0.0004472007,0.0002718704,0.00001791012,0.0001287821],"genre_scores_gemma":[0.9973562,0.0005949644,0.0005472047,0.0005955687,0.0003178122,0.00005807546,0.0001700137,0.00003498961,0.0003251882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5343598,"threshold_uncertainty_score":0.7543989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06093755690222046,"score_gpt":0.2742218536884167,"score_spread":0.2132842967861963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}