{"id":"W2412097653","doi":"10.1016/j.celrep.2016.05.028","title":"Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research","keywords":"Leishmania donovani; Biology; Immune system; Immunology; Cytokine; Innate immune system; Cell biology; B cell; Antibody; Visceral leishmaniasis; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002573743,0.0005510886,0.0003334014,0.0003992694,0.0001740834,0.0002529081,0.0001490407,0.0003700294,0.001138715],"category_scores_gemma":[0.0001461917,0.0002057214,0.0001960493,0.0001236097,0.00034111,0.0001991178,0.0003132376,0.0006917837,0.0002302366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002144923,"about_ca_system_score_gemma":0.0001306148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002191282,"about_ca_topic_score_gemma":0.0003693931,"domain_scores_codex":[0.9997815,0.00007467976,0.00001515553,0.000025219,0.0000315132,0.00007191759],"domain_scores_gemma":[0.9999017,0.00001734361,0.00002035385,0.00001078723,0.000008457174,0.00004131266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000615488,0.0002187836,0.00283104,0.0001059152,0.00001419565,0.0009228206,0.00005918947,0.00003343347,0.9926572,0.0001049611,0.00008405022,0.002352871],"study_design_scores_gemma":[0.0004365344,0.005183337,0.1700695,0.00007962273,0.0001949919,0.01071379,0.0004134671,0.001349435,0.8033805,0.0004646654,0.007691441,0.00002272865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974693,0.001126674,0.0001928501,0.00006988591,0.00001332941,0.00001824944,0.00003051861,0.00003011959,0.001048945],"genre_scores_gemma":[0.9986079,0.0004798151,0.00018375,0.00005485498,0.00001550677,0.00001702335,0.00005422061,0.000004044855,0.0005830009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001138715,"threshold_uncertainty_score":0.003809392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166191054406714,"score_gpt":0.2482279976957943,"score_spread":0.2365660871517272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}