{"id":"W2412097653","doi":"10.1016/j.celrep.2016.05.028","title":"Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research","keywords":"Leishmania donovani; Biology; Immune system; Immunology; Cytokine; Innate immune system; Cell biology; B cell; Antibody; Visceral leishmaniasis; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003979355,0.000287576,0.0004241615,0.0001264134,0.0001457303,0.00004678025,0.00008284757,0.0001012186,0.0002111689],"category_scores_gemma":[0.0007937638,0.0001895337,0.00008783778,0.0001909042,0.0002239089,0.0002759586,0.0001940198,0.0001795674,0.00004487822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001392913,"about_ca_system_score_gemma":0.0001624195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006261907,"about_ca_topic_score_gemma":0.00000294348,"domain_scores_codex":[0.9977127,0.00004962172,0.0005758284,0.0006291937,0.0005507706,0.0004818315],"domain_scores_gemma":[0.9981453,0.0002190998,0.0003025114,0.0006058095,0.0002843627,0.0004428986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002127093,0.0002516136,0.1135016,0.0002736695,0.00005821316,0.0008064533,0.0001127875,4.158305e-7,0.8499237,0.000007468069,0.02902852,0.005822891],"study_design_scores_gemma":[0.001878527,0.0002050039,0.1720781,0.0002526209,0.0001362272,0.0001002743,0.0001223106,0.00001244817,0.7466804,0.0003284136,0.07780908,0.0003965813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830561,0.005956823,0.00008959865,0.003830438,0.0001690552,0.0005998397,0.000008945726,0.0001381544,0.006151087],"genre_scores_gemma":[0.9770082,0.004009174,0.0002268929,0.0001504863,0.000177265,0.00006931768,0.00005039335,0.00005712061,0.01825113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1032433,"threshold_uncertainty_score":0.7728959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166191054406714,"score_gpt":0.2482279976957943,"score_spread":0.2365660871517272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}