{"id":"W2412248017","doi":"10.1002/bip.22891","title":"Evidence for a quadruplex structure in the polymorphic hs1.2 enhancer of the immunoglobulin heavy chain 3’ regulatory regions and its conservation in mammals","year":2016,"lang":"en","type":"article","venue":"Biopolymers","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Medical Research Council; Univerza v Ljubljani; Francis Crick Institute","keywords":"Enhancer; Genetics; Regulatory sequence; Gene; Biology; Transcription factor; Allele; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112561,0.0001502328,0.0001427685,0.0003469106,0.0001739658,0.0001673356,0.0001733611,0.0002969483,0.002787073],"category_scores_gemma":[0.0002569956,0.0001029555,0.0001534655,0.0001991736,0.0002280722,0.0001265828,0.0001334791,0.0003327501,0.0005701198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001240583,"about_ca_system_score_gemma":0.0001202216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002084043,"about_ca_topic_score_gemma":0.0003042087,"domain_scores_codex":[0.9999055,0.00001136495,0.000005904492,0.00003866403,0.00002846351,0.00001010469],"domain_scores_gemma":[0.9996408,0.00007038154,0.0001675105,0.00002784152,0.00003478412,0.00005854421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000162916,0.00004118141,0.00410117,0.00009165547,0.0000199885,0.0002566639,0.0000816609,0.0001107827,0.9893163,0.000444101,0.0001174419,0.005256209],"study_design_scores_gemma":[0.00006073908,0.001011977,0.2602808,0.0000486889,0.0001191473,0.007492633,0.0001833892,0.004991145,0.709504,0.00376943,0.01248134,0.00005660004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988735,0.00179888,0.006850657,0.00009983511,0.00002853961,0.00002317757,0.0004760945,0.0001413473,0.001846491],"genre_scores_gemma":[0.9941182,0.0001932469,0.004234354,0.00008548267,0.00002056642,0.00001236937,0.0006320373,0.00001508757,0.0006885746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002787073,"threshold_uncertainty_score":0.009323716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628480905143537,"score_gpt":0.2677569079457852,"score_spread":0.2414720988943498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}