{"id":"W2412403861","doi":"10.1021/acs.nanolett.5b04566","title":"Enzyme-Operated DNA-Based Nanodevices","year":2015,"lang":"en","type":"article","venue":"Nano Letters","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Seventh Framework Programme; European Research Council; Associazione Italiana per la Ricerca sul Cancro; Ministero della Salute","keywords":"Nanotechnology; Nanomedicine; DNA; Toolbox; Modularity (biology); DNA nanotechnology; Enzyme; DNA origami; Computational biology; Computer science; Materials science; Biology; Nanostructure; Biochemistry; Genetics; Nanoparticle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632093,0.000155063,0.0001335366,0.00005554169,0.00005356073,0.00003060541,0.000155081,0.0001155601,0.000002260955],"category_scores_gemma":[0.000052262,0.0001289124,0.00008343993,0.0001512611,0.00008483433,0.000003766671,0.00003875528,0.00004656209,0.00001489576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002191447,"about_ca_system_score_gemma":0.00005715358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001555519,"about_ca_topic_score_gemma":0.00002113518,"domain_scores_codex":[0.9991006,0.00006010858,0.0001526414,0.0003134849,0.000155476,0.0002176858],"domain_scores_gemma":[0.9994108,0.000005247898,0.00006515256,0.0003178481,0.0001035162,0.00009741691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004194604,0.00002465752,0.0005407242,0.000003226496,0.00002329186,0.00000588713,0.000007361208,0.000059505,0.9775965,0.000003326562,0.02096633,0.0007272332],"study_design_scores_gemma":[0.0003402751,0.00009907495,0.00005393345,0.000009206673,0.00001759249,0.000005203057,0.00001924988,0.00005343947,0.9119448,0.000004130887,0.08726707,0.0001860303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932441,0.0001851032,0.003541055,0.002222504,0.0001004609,0.00009040964,0.000009603603,0.00009234794,0.0005144448],"genre_scores_gemma":[0.9849768,0.000008831052,0.005626518,0.008780859,0.0001609667,0.000006649527,0.000147951,0.0000192043,0.0002722137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06630073,"threshold_uncertainty_score":0.5256893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423319768389627,"score_gpt":0.2608201735268021,"score_spread":0.2465869758429058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}