{"id":"W2412642891","doi":"10.1182/blood.v122.21.2670.2670","title":"Zebrafish Xenotransplantation and Focused Chemical Genomics: A Preclinical Therapeutic Model For T-Cell Acute Lymphoblastic Leukemia","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Zebrafish; Biology; Xenotransplantation; Cancer research; PTEN; Leukemia; T cell; Molecular biology; In vivo; PI3K/AKT/mTOR pathway; Immune system; Immunology; Transplantation; Cell biology; Genetics; Signal transduction; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004325662,0.0006594559,0.0003721581,0.0006407922,0.0004030385,0.0004044412,0.0004792915,0.0007011193,0.00210907],"category_scores_gemma":[0.0001685325,0.0002778256,0.0005702958,0.0002484359,0.000523865,0.0003151943,0.0003821097,0.001191618,0.0005050458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001000984,"about_ca_system_score_gemma":0.0005950465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003207414,"about_ca_topic_score_gemma":0.004232353,"domain_scores_codex":[0.99971,0.00004402868,0.00001930485,0.00006342675,0.0001090636,0.00005417805],"domain_scores_gemma":[0.9998794,0.00002353448,0.0000328585,0.00001844187,0.00001534142,0.00003042914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001238438,0.00005335607,0.0001628943,0.00003851044,0.000006458022,0.0001307828,0.00002445665,0.0002725334,0.9974534,0.0004680322,0.0001557424,0.001110001],"study_design_scores_gemma":[0.00008998088,0.001570208,0.002336912,0.00001798535,0.00004645214,0.0007190371,0.00004423263,0.002693904,0.9834135,0.0002338684,0.008813832,0.00002009829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9357027,0.001912376,0.04757787,0.0008879993,0.0002487164,0.0009266963,0.004286394,0.0009416236,0.007515596],"genre_scores_gemma":[0.9574753,0.001890797,0.0279247,0.0002522142,0.00002067792,0.0009212529,0.002172648,0.0001479048,0.009194545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003207414,"threshold_uncertainty_score":0.007262707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662689734966697,"score_gpt":0.275446637694996,"score_spread":0.258819740345329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}