{"id":"W2412674086","doi":"10.1385/1-59745-187-8:249","title":"Synthesis of Degenerated Libraries of the <i>Ras</i>-Binding Domain of <i>Raf</i> and Rapid Selection of Fast-Folding and Stable Clones With the Dihydrofolate Reductase Protein Fragment Complementation Assay","year":2006,"lang":"en","type":"article","venue":"Humana Press eBooks","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Phage display; Computational biology; Dihydrofolate reductase; Directed evolution; Protein engineering; Biology; Folding (DSP implementation); Molecular biology; Biochemistry; Enzyme; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004143544,0.0007927872,0.0009460079,0.0005511945,0.0002633814,0.0003691118,0.0007520191,0.0004049084,0.002645966],"category_scores_gemma":[0.0003453549,0.0003909922,0.0006859034,0.0007803772,0.0002820077,0.0002438824,0.0004872415,0.001061475,0.002890426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205411,"about_ca_system_score_gemma":0.0003726167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003032265,"about_ca_topic_score_gemma":0.00062427,"domain_scores_codex":[0.9994474,0.00008387041,0.00006558737,0.0001215859,0.0001804459,0.0001011423],"domain_scores_gemma":[0.9998023,0.00004983063,0.0000349788,0.0000421501,0.00004079076,0.00003010994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004819582,0.00003433904,0.00005028419,0.00007083516,0.000007924325,0.00006872287,0.00002616653,0.0001569017,0.9949884,0.0002252184,0.0001279397,0.004195099],"study_design_scores_gemma":[0.00001301561,0.0001671452,0.0004367816,0.000006667496,0.00002618466,0.0002027465,0.00001379887,0.0006624985,0.9901895,0.00007818652,0.008189933,0.00001352849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6900985,0.003308099,0.2799847,0.0003243624,0.0002614136,0.001836135,0.009571278,0.002215935,0.01239938],"genre_scores_gemma":[0.6730227,0.003816837,0.2391791,0.0003826728,0.00005856402,0.001610194,0.04295631,0.0009640875,0.03800949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002645966,"threshold_uncertainty_score":0.008851647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02420329290833707,"score_gpt":0.2512132189484633,"score_spread":0.2270099260401262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}